Is warfarin used as rat poison? - Drugs.com
2023年5月30日 · As in humans, warfarin use stops normal blood clotting in rodents and leads to death, but may require several doses in rodents. Although rodents play important roles in …
Warfarin: from rat poison to clinical use - Nature
2017年12月14日 · The anticoagulant drug warfarin is widely used to prevent and treat deep-vein thrombosis and pulmonary embolism, and to prevent stroke in patients who have atrial …
Is Warfarin Really Rat Poison? - The Medication Insider
Q: I’m on warfarin. Is it true that I’m taking RAT POISON? YES, you’re taking a medicine that originally was used to kill rats. We know warfarin, by the brand names Coumadin® and …
Intestinal toxicity of oral warfarin intake in rats - ScienceDirect
2016年8月1日 · In this work, the effects of 30 days oral warfarin (0.35 mg/l and 3.5 mg/l) intake on rat’s gut were examined. Both doses resulted in prolongation of prothrombin time. Systemic …
Toxic effects of warfarin in rats fed different diets
1974年6月1日 · Warfarin, 3- (a-acetonylbenzyl)4-hydroxycoumarin, has been found to have a more potent anticoagulating action in rats than dicumarol, 3,3'-methylenebis- (4 …
Warfarin exposure and calcification of the arterial system in the rat
1999年8月20日 · The aim of this study was to determine if a warfarin treatment regimen in rats, designed to cause extra-hepatic vitamin K deficiency, would also cause arterial calcification. …
In 1951, a US Army inductee attempted suicide with multiple doses of warfarin in rodenticide, but fully recovered after being treated with vitamin K in hospital. Studies then began on the use of...
Strain differences in intestinal toxicity of warfarin in rats
2016年12月1日 · Data from the present study showed that AO and DA rats differed in the susceptibility to warfarin-induced hemorrhage, in the direct toxicity of warfarin to intestine and …
Mutant Rats Resist Warfarin - ScienceDaily
2009年2月17日 · A new series of mutations have been discovered that allow rats to resist the effects of the popular poison warfarin. New research describes eighteen new genetic changes …
Strain differences in intestinal toxicity of warfarin in rats
Having in mind genetic variations in the effectiveness of WF in wild rats and in the doses required for therapeutic effect, strain differences in the intestinal toxicity of oral warfarin in rats were …