Under typical physiological conditions, acetoacetic acid exists as its conjugate base, acetoacetate: Ac CH 2 CO 2 H → AcCH 2 CO − 2 + H + Unbound acetoacetate is primarily produced by liver mitochondria from its thioester with coenzyme A (CoA):

Acetoacetate | C4H5O3- | CID 6971017 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

糖尿病 患者の血液中にアセト酢酸が多く、尿中にも排出されてくる。 生体内では、二分子のアセチルCoAから作られる。 糖尿病の場合ではインスリンが欠乏しているために肝臓、筋肉といった組織が血糖を取り込むことができず、脂肪酸からβ酸化によりアセチルCoAに分解して大量のアセチルCoA ...

2022年9月24日 · Acetoacetate is the first ketone body that your liver produces. During the first few days of keto dieting (or fasting), you are much more likely to create and excrete more acetoacetate and acetone (a spontaneously formed ketone that is virtually useless).

2024年10月23日 · Acetoacetate is the first ketone produced in the body during ketosis. It’s important because it’s the precursor to beta-hydroxybutyrate, which is a vital energy carrier when you’re in ketosis. Acetoacetate is completely safe, but it is commonly confused with ethyl acetoacetate, which has various health warnings.

2019年5月6日 · Acetoacetic acid (=acetoacetate) is a weak Beta-keto acid produced from acetyl-CoA in the mitochondrial matrix of hepatocytes. When there is decreased availability of glucose or impaired glucose metabolism, such as in diabetes mellitus, the acetyl-CoA is diverted to produce more acetoacetate, from which acetone and beta-hydroxybutyrate are formed.

Acetoacetate is a compound used in a chemical system to determine trichothecene mycotoxins like deoxynivalenol (DON) and nivalenol (NIV) in food samples. It reacts with formaldehyde and ammonium to form fluorescent dihydropyridine derivatives in a two-step modified Hantzsch synthesis process.

Keywords: Acetoacetate, Glycolysis, Oxidation, ROS, Stem cells. Highlights • Human mesenchymal stem cells oxidise acetoacetate 35 times faster than glucose. • Oxidation of acetoacetate reduces ROS-production 45-fold compared with glucose. • Acetoacetate plus pyruvate is the optimal substrate combination for ATP-production. •

Acetoacetate (AcAc) was discovered in 1865 in the urine of patients suffering from catastrophic diabetes mellitus. The accumulation of β-hydroxybutyrate (β-OHB) in the urine during 2–3 days of fasting was recognized in 1887.

It is a conjugate acid of an acetoacetate. It is a tautomer of a 3-hydroxy-3-butenoic acid.