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    https://en.wikipedia.org › wiki › Aminoglycoside

    Aminoglycoside - Wikipedia

    • Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some Mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Streptomycin was the first effective drug in the treatment of tuberculosis, though ...… 展开

    Overview

    Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside… 展开

    Mechanisms of action

    Aminoglycosides display concentration-dependent bactericidal activity against "most gram-negative aerobic and facultative anaerobic bacilli" but not against gram-negative anaerobes and most gram-positive bacteria… 展开

    Routes of administration

    Since they are not absorbed from the gut, they are administered intravenously and intramuscularly. Some are used in topical preparations for wounds. Oral administration can be used for gut decontaminatio… 展开

    What are the side effects of aminoglycosides?
    Impairment of kidney function and hearing loss are the most common side effects of aminoglycosides. Aminoglycosides tend to be used when other less toxic antibiotics are contraindicated or ineffective. Aminoglycosides are not well absorbed when given by mouth, so need to be given by injection by healthcare personnel.
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