Biglycan is a small leucine-rich repeat proteoglycan (SLRP) which is found in a variety of extracellular matrix tissues, including bone, cartilage and tendon. In humans, biglycan is encoded by the BGN gene [5] which is located on the X chromosome.

2023年11月13日 · BGN （Biglycan）作为一种重要的 细胞外基质蛋白 ，近年来引起了科学家们的广泛兴趣。艾普蒂生物系统地研究了BGN重组蛋白（现货目录号：PA1000-3767）的生物学功能，并探讨了其在不同疾病治疗中的潜在应用。

Proteolytically released from the ECM, biglycan acts as a danger signal signifying tissue stress or injury. As a ligand of innate immunity receptors and activator of the inflammasome, biglycan stimulates multifunctional proinflammatory signaling linking the …

双糖链蛋白聚糖是2008年公布的生物化学与分子生物学名词。 一种存在于细胞基质中的小型蛋白聚糖，含有一条或两条硫酸软骨素或硫酸皮肤素糖链。 在软骨、主动脉和骨的矿化区间相当丰富。 一种存在于细胞基质中的小型蛋白聚糖，含有一条或两条硫酸软骨素或硫酸皮肤素糖链。 在软骨、主动脉和骨的矿化区间相当丰富。 《生物化学与分子生物学名词》。 双糖链蛋白聚糖是2008年公布的生物化学与分子生物学名词。

Biglycan是一种原型细胞外基质衍生的损伤相关分子模式，它通过Toll样受体（TLR）2和/或TLR4依赖性信号通路介导巨噬细胞中的无菌炎症。 在这里，我们发现可溶性双链糖蛋白是CD14的新型高亲和力配体，CD14是TLR的著名GPI锚定共受体。

Biglycan is a core protein with leucine-rich repeats and chondroitin/dermatan sulfate side chains, found in the extracellular matrix of various tissues. It plays a key role in regulating collagen fibril assembly and interacts with cytokines to modulate diverse biological functions.

Biglycan, a class I small leucine-rich proteoglycans (SLRP), is a key component of the ECM that participates in scaffolding the collagen fibrils and mediates cell signaling. Dysregulation of biglycan expression can result in wide range of clinical conditions such as metabolic disorder, inflammatory disorder, musculoskeletal defects and ...

Soluble biglycan, a small leucine-rich proteoglycan, plays a significant role in several pathologies as it has emerged as an extracellular matrix-derived danger-associated molecular pattern. Biglycan is released from the extracellular matrix in response to …

2021年6月1日 · The role of soluble biglycan in regulating both pro- and anti-inflammatory response is prototypically illustrated by its regulation of the pro-inflammatory master cytokine IL-1β. Biglycan, on one side, directly triggers pro-IL-1β production via TLR2/4 [49].

Proteolytically released from the ECM, biglycan acts as a danger signal signifying tissue stress or injury. As a ligand of innate immunity receptors and activator of the inflammasome, biglycan stimulates multifunctional proinflammatory signaling linking the …