Brucine is an alkaloid closely related to strychnine, most commonly found in the Strychnos nux-vomica tree. Brucine poisoning is rare, since it is usually ingested with strychnine, and strychnine is more toxic than brucine. In chemical synthesis, it can be used as a tool for stereospecific chemical syntheses.

正如早期研究人員指出的那樣，番木鳖碱分子結構及其特定的環、立體中心和氮官能基陣列，是一個複雜的合成靶標，因此激發了人們對其藥理活性背後的結構-活性關係的興趣 [2] 。 早期針對番木鳖碱的合成化學家罗伯特·伯恩斯·伍德沃德(R.B. Woodward)引用了透過化學分解和相關物理研究確 …

Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents of Nux-vomica. Modern pharmacology studies and clinical practice demonstrate that brucine possesses wide pharmacological activities, such as anti-tumor, anti-inflammatory, analgesic, and the effects on cardiovascular system and nervous system, etc.

2009年4月8日 · Brucine | C23H26N2O4 | CID 442021 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2023年11月1日 · Brucine is a vomiting inducing agent and used in many poison withdrawing cases by inducing vomiting. Brucine has potent anti-inflammatory and analgesic activity. It also possesses anti-cancer activity against many cell lines of cancers. Some of the activities of brucine are discussed below.

This paper reviews the function of brucine and its anti-tumor preparations, and compares the efficacy and adverse reactions between brucine related preparations and traditional drugs to evaluate its anti-tumor effects. Furthermore, more exploration on the inhibiting mechanisms is necessary for the patients to obtain safe and effective drugs.

2020年4月3日 · Brucine是一种弱碱性的吲哚生物碱，是Nux-vomica的主要生物活性和有毒成分之一。 现代药理研究和临床实践表明，马钱子碱具有广泛的药理活性，例如抗肿瘤，抗炎，镇痛作用以及对心血管系统和神经系统的影响等。

2023年7月29日 · 马钱子碱（brucine）作为马钱子的主要成分之一，其抗肿瘤活性远高于士的宁、马钱子碱氮氧化物等其他马钱子中生物碱成分 [2] ，且毒性远低于士的宁 [3] ，成为抗肿瘤研究的一个热点。现就近年关于马钱子碱及其制剂的抗肿瘤研究进行综述。

中文名:二甲氧基马钱子碱,英文名:Brucine,CAS:357-57-3,化学式:C23H26N2O4,分子量:394.46,密度:1.2119 (rough estimate),熔点:175-178°C (dec.)(lit.),沸点:518.67°C (rough estimate),闪点:337.1°C,水溶性:Soluble in alcohol, chloroform, and benzene, slightly soluble in water, ether, and glycerol,蒸汽压:5.76E-16mmHg at 25 ...

2020年4月3日 · Brucine is a traditional medicinal herb extracted from seeds of Strychnos nux-vomica L. (Loganiaceae) exhibiting antitumor activity in a variety of cancer models.