Chymases (EC 3.4.21.39, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in …

2018年1月19日 · Chymase is the most efficient Ang II (angiotensin II)–forming enzyme in the human body and has been implicated in a wide variety of human diseases that also implicate its many other protease action...

为胰腺分泌的一种蛋白水解酶，能迅速分解变性蛋白质，作用、用途与胰蛋白酶相似，比胰蛋白酶分解能力强、毒性低、不良反应小。糜蛋白酶用途广泛，尚可用于扭伤、中耳炎、鼻炎、鼻窦炎、咽炎、肺脓疡等治疗。可用于外科炎症、创伤、血肿及脓肿等，也可用于气管切开术。

Chymase, a member of serine proteases primarily secreted by mast cells, exhibits a twenty-fold higher catalytic efficiency for conversion of Ang I into Ang II [66,67] by its preference for phenylalanine or leucine being in the P1 position (proximate to the scissile bond) according to the Schechter and Berger nomenclature system . Of note, while ...

Chymase is a chymotrypsin-type serine protease mainly localized in mast cells (MCs). Human, primate, and dog chymase generate angiotensin II (Ang II) from Ang I, while mouse and rat chymases degrade Ang II. It is suggested that chymase generating Ang II might be an alternative Ang II-forming enzyme …

Although chymase alone does not cause a wheal when injected into skin, it greatly increases the size of the wheal caused by co-injected histamine; furthermore, chymase inhibitors decrease wheals induced by allergen. Thus it appears that chymase can worsen allergic inflammation by acting in conjunction with other inflammatory products of mast cells.

Chymase is a chymotrypsin-like neutral protease that is found in a specific subset of human mast cells. It has the ability to cleave matrix components and activate enzymes involved in matrix remodeling. Additionally, chymase can activate angiotensin I, leading to the independent activation of angiotensin II.

Chymase is a chymotryptic protease of mast cells whose roles in asthma have been less extensively studied than tryptase, but it is expressed by those mast cells infiltrating the ASM in asthma. 9 Interestingly, chymase degrades human ASM pericellular matrix and inhibits T-cell adhesion to ASM, which might explain the paucity of T cells within ...

2019年8月8日 · Chymase provides cleavage of the components of glycocalyx produced by the epithelial cells of the respiratory pathways and stimulates the secretory activity of the glands of the respiratory mucous membrane (Fig. 3h) (Welle 1997). Chymase is able to increase the epithelium penetration of the lamina propria of the mucous membrane (Fu et al. 2015 ...

Chymase is a protein-digester enzyme found primarily in mast cells (MC), fibroblasts, and vascular endothelial cells. Chymase is released into the extracellular stroma in the context of inflammatory signals, tissue injury and cellular stress.