7-Dehydrocholesterol (7-DHC) is a zoosterol that functions in the serum as a cholesterol precursor, and is photochemically converted to vitamin D 3 in the skin, therefore functioning as provitamin -D 3. The presence of this compound in human skin enables humans to manufacture vitamin D 3 (cholecalciferol).

2024年1月31日，通讯作者为同济医学院的王平教授在《Nature》发表了题为“7-Dehydrocholesterol dictates ferroptosis sensitivity”的文章。 铁死亡的重要标志是铁依赖的磷脂过氧化，导致生物膜的破坏。

2024年1月31日 · Here, using genome-wide CRISPR–Cas9 screening, we identified that the enzymes involved in distal cholesterol biosynthesis have pivotal yet opposing roles in regulating ferroptosis through dictating...

7-脱氢胆固醇（英語： 7-Dehydrocholesterol ，缩写7-DHC）是一种胆固醇合成的前体 [1] [2] ，同时也是维生素D 3 （胆钙化醇）合成的中间产物，会在光照下开环转化为维生素D 3 。

Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC). Although previous studies suggested that high concentrations of 7-DHC are cytotoxic to developing neurons by favouring lipid peroxidation3, we now show that 7-DHC accumulation ...

2024年1月31日 · Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC).

2024年4月4日 · Li et al. and Freitas et al. recently identified 7-dehydrocholesterol (7-DHC), a sterol produced through the cholesterol biosynthetic pathway, as a lipid-soluble antioxidant that protects cells from ferroptosis, a cell death pathway triggered by …

二氢胆固醇，又叫二氢胆甾醇，化学式为C27H48O，在体内的作用尚不清楚，可能与胆酸和某些激素的形成有关。

2025年2月1日 · 7-Dehydrocholesterol (7-DHC), is one of the prominent sterols found in the epidermis and dermis of human beings (Lange, 2012) (Fig. 1 A). When exposed to sunlight, 7-DHC is transformed into vitamin D 3, which plays a crucial role in regulating calcium and phosphorus metabolism in humans (Bendik et al., 2014).

7-Dehydrocholesterol | C27H44O | CID 439423 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.