Glial Cell Communities Conspire to Drive Alzheimer’s Disease
2024年9月26日 · Less well understood is what role inflammation and glial changes play. Now, by analyzing single-nuclei RNA-Seq data from more than 400 postmortem brains, scientists have homed in on specific glial subtypes associated with distinct stages of AD pathology, estimating the effects subtypes have on plaques, tangles, and cognition.
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
2024年10月22日 · When they cranked up tau expression in glia throughout the fly brain, glial lipid droplets plummeted by more than 90 percent, and peroxidated lipids accumulated. Similarly, in co-cultures of rat primary cells grown in a salt solution that provokes mild oxidative stress, overexpressing tau in astrocytes slashed production of lipid droplets.
Sans Plexin-B1, Glial Net Tightens Around Plaques - ALZFORUM
2024年6月1日 · In APP/PS1 controls (left), astrocytes (green) and microglia (brown) form a wide glial net around plaques. Without Plexin-B1 to enforce cell spacing (right), glia crowd together and around plaques, compacting them more. [Courtesy of Huang et al., Nature Neuroscience, 2024.] This potency manifested in the plaque load.
Glial lipid droplets resolve ROS during sleep. - ALZFORUM
2024年2月27日 · The daily transfer of lipids from neurons to glia required neuronal lazarillo (NLaz), a fly apolipoprotein similar to human apolipoprotein E (APOE): knocking down NLaz reduced glial lipid droplet accumulation. Interestingly, reducing the expression of glial lazarillo (GLaz) resulted in more lipid droplets rather than fewer, which was unexpected.
Do Activated Glia Contribute to Long COVID? | ALZFORUM
2023年6月8日 · Some people become depressed after COVID-19. The cause remains a mystery, but now a small PET study hints that glia might be involved. In the May 31 JAMA Psychiatry, scientists led by Jeffrey Meyer at the University of Toronto reported high levels of the glial translocator protein, a marker for gliosis, in 20 people two years after COVID.
Don’t Name It: Glial States Confound Easy Labels - ALZFORUM
2022年7月22日 · In particular, both papers cautioned against the lure of easy dichotomies, of categorizing glial cells as resting versus activated, or protective versus toxic. The more scientists learn, the more apparent it becomes that these labels are oversimplifications of complex and dynamic states, which can be beneficial or detrimental in different contexts.
Tau is required for glial lipid droplet formation and resistance to ...
2024年10月22日 · Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress. Nat Neurosci. 2024 Oct;27(10):1918-1933. Epub 2024 Aug 26 PubMed. Recommends. Please login to recommend the paper. Comments. Amita Sehgal University of Pennsylvania; Posted: 22 Oct 2024; News: New Role for Tau: Making Lipid Droplets in Glia?
Newborn Neurons in the Adult Brain: Real Deal, or Glial Imposters?
2018年4月12日 · Glial Impostor? DCX+ (green) cells co-expressing the oligodendrocyte marker Olig2 (red). [Courtesy of Sorrells et al., Nature, 2018.] The researchers concluded that neurogenesis is robust only in the earliest stages of development, and that DCX+ cells in late childhood and adult samples were actually glia.
Not Just a Biomarker: YKL-40 Links Glial Clock to Amyloidosis
2020年12月22日 · Further, deleting the YKL-40 gene, Chi3l1, alters glial inflammatory responses, promotes astrocyte and microglial phagocytosis of Aβ, and mitigates amyloid plaque formation—at least in mice. The findings, reported in the December 16 Science Translational Medicine, connect the circadian clock to glial responses in AD.
Neurons Need Cholesterol from Glia to Make Synapses
2002年7月7日 · A paper in tomorrow's Science presents a new, beneficial function for cholesterol in the brain that may help explain some previous data. Scientists led by Frank Pfrieger the Max-Planck/CNRS group in Strasbourg, France, report that neurons need cholesterol secreted by glial cells to form and maintain functional synapses.