The cytoplasmic peptide: N -glycanase (NGLY1); structure, …
2016年2月2日 · NGLY1/Ngly1 is a cytosolic peptide: N -glycanase, i.e. de- N -glycosylating enzyme acting on N -glycoproteins in mammals, generating free, unconjugated N -glycans and deglycosylated peptides in which the N -glycosylated asparagine residues …
The cytoplasmic peptide:N-glycanase (NGLY1) - ScienceDirect
2016年2月10日 · NGLY1/Ngly1 is a cytosolic peptide: N -glycanase, i.e. de- N -glycosylating enzyme acting on N -glycoproteins in mammals, generating free, unconjugated N -glycans and deglycosylated peptides in which the N -glycosylated asparagine residues …
NGLY1 Gene - GeneCards | NGLY1 Protein | NGLY1 Antibody
2024年10月2日 · NGLY1 (N-Glycanase 1) is a Protein Coding gene. Diseases associated with NGLY1 include Congenital Disorder Of Deglycosylation 1 and Ngly1-Deficiency. Among its related pathways are Metabolism of proteins and Calnexin/calreticulin cycle.
NGLY1 mutations cause protein aggregation in human neurons
Biallelic mutations in the gene that encodes the enzyme N-glycanase 1 (NGLY1) cause a rare disease with multi-symptomatic features including developmental delay, intellectual disability, neuropathy, and seizures. NGLY1’s activity in human neural cells is currently not well understood.
Physiological and molecular functions of the cytosolic peptide:N-glycanase
2015年5月1日 · Peptide: N -glycanase (PNGase) is a deglycosylating enzyme that acts on N -glycoproteins.
The cytoplasmic peptide:N-glycanase (NGLY1) - Structure
2016年2月10日 · NGLY1/Ngly1 is a cytosolic peptide:N-glycanase, i.e. de-N-glycosylating enzyme acting on N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated peptides in which the N-glycosylated asparagine residues …
A role for N -glycanase in the cytosolic turnover of glycoproteins
N-glycanase recognizes high-mannose type glycans on misfolded proteins. We also examined the class I MHC heavy chain as a suitable N-glycanase substrate.
N-glycanase NGLY1 regulates mitochondrial homeostasis and …
2024年10月18日 · The N-glycanase 1 (NGLY1), also known as peptide:N-glycanase (PNGase), is an evolutionarily conserved enzyme that removes N-glycans from glycosylated proteins in the cytosol (Suzuki et al., 2016). NGLY1 plays a crucial role …
Enzyme assay of endogenous activity of peptide-N-glycanase …
2021年9月15日 · The cytosolic peptide: N -glycanase (PNGase; NGLY1 in mammal) is an enzyme that catalyzes the hydrolysis of an amide bond between glycosylated asparagine residues on proteins and proximal GlcNAc residues of N -glycans (1).
NGLY1 gene - MedlinePlus
The NGLY1 gene provides instructions for making an enzyme called N -glycanase 1. Learn about this gene and related health conditions.
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