MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound. It is classified as a tetrahydropyridine. It is of interest as a precursor to the monoaminergic neurotoxin MPP +, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain.

MPTP, which is lipid-soluble, readily penetrates the blood—brain barrier and enters the brain cells. Because it is amphiphilic, it is captured into acidic organelles, mostly lysosomes, of astrocytes.

The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of the mitochondria under certain pathological conditions such as traumatic brain injury and stroke.

The identification of MPTP, a relatively simple compound which causes selective degeneration of the substantia nigra after systemic administration, has had an a significant impact on the understanding and treatment of Parkinson’s disease (PD) over the last 30 years.

2001年12月1日 · 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes damage to substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons as seen in Parkinson's disease (PD).

The MPTP Model of Parkinsonism Is the Gold Standard Preclinical Model. An important outcome of discovering MPTP was the generation of an animal model of parkinsonism. The MPTP model has been key to understanding the pathophysiology of PD, as well as an essential tool for drug development in PD.

The discovery of MPTP-induced parkinsonism was the basis of a paradigm shift in Parkinson's disease research, which started with careful clinical observation of the seven index cases. As an historical tribute, we present unique video footage of five of these patients (appendix).

MPTP causes damage to substantia nigra pars compacta (SNpc) dopaminergic (DA) neurons as seen in Parkinson's disease (PD). After sys-temic administration of MPTP, its active metabolite, MPP +, accumulates within SNpc DA neurons, where it inhibits ATP production and stim-ulates superoxide radical for …

The identification of MPTP, a relatively simple compound which causes selective degeneration of the substantia nigra after systemic administration, has had an a significant impact on the understanding and treatment of Parkinson’s disease (PD) over the last 30 years.

2021年10月24日 · The study of neurotoxicity induced by MPTP led to drastically change the perspective on Parkinson’s disease. In fact, the selective neurotoxicity induced by MPTP rejuvenated PD research and generated a number of studies aimed at elucidating the mechanisms of...