Myoglobinuria is the presence of myoglobin in the urine, which usually results from rhabdomyolysis or muscle injury. [1] . Myoglobin is present in muscle cells as a reserve of oxygen. Signs and symptoms of myoglobinuria are usually nonspecific and needs some clinical prudence.

Myoglobinuria refers to an abnormal pathologic state in which there is an excessive amount of myoglobin is found in the urine, imparting a cola-like urine color. Myoglobin is a dark, small, oxygen-binding red cytoplasmic heme protein found only in heart and skeletal muscles 1.

2023年10月6日 · When excreted into the urine, myoglobin, a monomer containing a heme molecule similar to hemoglobin, can precipitate, causing tubular obstruction and acute kidney injury.

Myoglobinuria is a medical condition characterized by the presence of myoglobin in the urine, often resulting from muscle damage. This condition can be a clinical marker for several underlying health issues and, if left unaddressed, can lead to serious complications.

Myoglobinuria is usually the result of rhabdomyolysis or muscle destruction. The cause can be either hereditary or acquired. A typical myoglobinuria presents classical triad of symptoms like myalgia, muscle weakness and tea red colour urine [2, 3].

2023年10月6日 · Initial treatment focuses on preventing myoglobin precipitation in the urine by inducing and maintaining a brisk diuresis. Immediately administer saline to patients with suspected myoglobinuria...

1993年9月6日 · Rhabdomyolysis refers to the breakdown of striated muscle that is followed by leakage of the muscle protein myoglobin into the blood, leading to its excretion in the urine. This phenomenon is called myoglobinuria.

Rhabdomyolysis (Myoglobinuria), Child-onset, Recurrent 24 Lipin-1 (LPIN1) ; Chromosome 2p25.1; Recessive Epidemiology Common cause of rhabdomyolysis in children: > 35 patients; > 30 families; 37% of rhabdomyolysis patients: Age ≤ 6 years & Serum CK > 10,000; Ethnic origins: Many Genetics LPIN1 mutations

Myoglobinuria refers to an abnormal pathologic state in which an excessive amount of myoglobin is found in the urine, imparting a cola-like hue, usually in association with myonecrosis and a clinical picture of weakness, myalgias, and edema.

2023年10月6日 · Myoglobinuria is usually the result of rhabdomyolysis or muscle destruction. Any process that interferes with the storage or use of energy by muscle cells can lead to myoglobinuria.