The nitrergic system refers to the inhibitory enteric neurons embedded in the muscle of the gut wall which play a critical role in gastric motility (gastric accommodation, pyloric relaxation) [62].

The nerves whose transmitter function depends on the NO release are called "nitrergic", and such nerves are recognized to play major roles in the control of smooth muscle tone and motility and of fluid secretion in the GI tract.

2019年4月24日 · Nitrergic enteric neurons are key players of the descending inhibitory reflex of intestinal peristalsis, therefore loss or damage of these neurons can contribute to developing gastrointestinal motility disturbances suffered by patients worldwide. There is accumulating evidence that the vulnerability …

2019年4月24日 · Nitrergic enteric neurons are key players of the descending inhibitory reflex of intestinal peristalsis, therefore loss or damage of these neurons can contribute to developing gastrointestinal motility disturbances suffered by patients worldwide.

2014年10月23日 · The present review article includes recent advances in research on the functional importance of nitrergic nerves concerning the control of cerebral blood flow, as well as other regions, and vascular resistance. Although information is still insufficient, the nitrergic nerve histology and function in vasculatures of non-mammals are also summarized.

Nitrergic neurons also innervate the reproductive tract of females and males. 34, 35 Parasympathetic, nitrergic immunoreactive neurons originate from the pelvic paracervical ganglia and innervate the uterine artery. Pregnancy and estrogen treatments augment the activity of calcium-dependent NOS activity in uterine arteries.

Functioning of nitrergic vasodilator nerves is evidenced in several territories, including cerebral, mesenteric, pulmonary, renal, penile, uterine and cutaneous arteries. Nitric oxide (NO) is the main neurogenic vasodilator in cerebral arteries and acts as a counter-regulatory mechanism for adrenergic vasoconstriction in other vascular territories.

A nitrergic neuron is a type of neuron present in the InM that provides input to the NTS and is involved in coordinating autonomic responses to activation of sensory structures within the neck. You might find these chapters and articles relevant to this topic. Nitrergic neurons have been found in the spinal cord [41,58,203,244].

Nitrergic nerves are believed to represent the main nervous bronchodilator pathway in humans, and dysfunction of this system may be implicated in the increased tone and hyper-responsiveness observed in asthma (Belvisi et al., 1995).

Nitrergic regulation is extremely important in GI motility, as NO is a major inhibitory neurotransmitter in nearly every region and a mediator of inflammatory effects. NOS + motor neurons are plentiful in GI muscles, and they release NO when activated. Postjunctional responses in cells of the SIP syncytium are activated by NO.