2024年10月21日 · Here, we show that peptidylprolyl isomerase A (PPIA) serves as anchor to recruit GAU1 lncRNA by interacting with exon 4 of GAU1 and enhances the formation of SENP5/GAU1 DNA-lncRNA triplex....

2024年10月21日，同济大学生命科学与技术学院张赫教授团队在《自然·通讯》（Nature Communications）上发表了题为“Peptidylprolyl isomerase A guides SENP5/GAU1 DNA-lncRNA triplex generation for driving...

2024年12月25日 · PPIA (Peptidylprolyl Isomerase A) is a Protein Coding gene. Diseases associated with PPIA include Influenza and Measles. Among its related pathways are HIV Life Cycle and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include RNA binding and peptide binding.

催化肽酰脯氨基顺反异构化的酶，广泛存在于各种组织和器官。 根据对免疫抑制剂的敏感性，分属三个独立的家族：亲环蛋白、FK506结合蛋白和细蛋白。 能够加速自身折叠和体内新生肽链折叠及变性蛋白质的体外折叠。 编号：EC5.2.1.8。 催化肽酰脯氨基顺反异构化的酶，广泛存在于各种组织和器官。 根据对免疫抑制剂的敏感性，分属三个独立的家族：亲环蛋白、FK506结合蛋白和细蛋白。 能够加速自身折叠和体内新生肽链折叠及变性蛋白质的体外折叠。 肽基脯氨酰基顺反异 …

Three distinct families of PPI enzymes (parvulins, cyclophilins, and FK506-binding proteins (FKBPs)) each have the capacity to catalyze cis-trans proline isomerization in substrate proteins, and this modification can regulate both structure and function.

2021年3月15日 · Our findings demonstrate that the PPIAP22/miR-197-3p/PPIA axis plays a vital role in the progression of HCC by increasing the malignancy of tumor cells and regulating the immune cell infiltration, especially macrophage, through CCL15-CCR1 or CXCL12-CXCR4/CXCR7 pathways. Keywords: PPIA; chemokine; …

2014年11月5日 · Peptidyl-prolyl cis / trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of cellular function and pathophysiology of disease.

2024年12月25日 · PPIB (Peptidylprolyl Isomerase B) is a Protein Coding gene. Diseases associated with PPIB include Osteogenesis Imperfecta, Type Ix and Brittle Bone Disorder. Among its related pathways are Infectious disease and SARS-CoV-1-host interactions. Gene Ontology (GO) annotations related to this gene include RNA binding and unfolded protein binding.

2021年6月10日 · In this study, we carried out genome-wide analysis of PPIases in different Penicillium spp. and investigated their regulation by salt stress in a halotolerant strain of Penicillium oxalicum.

Peptidyl-prolyl isomerases (PPIs) are ubiquitous proteins expressed in prokaryotic and eukaryotic cells alike. Their primary catalytic function is to facilitate the cis–trans isomerisation of peptide bonds N-terminal to proline (Pro) residues within polypeptide chains (see Figure 1).

该基因编码肽基-脯氨酰顺反异构酶 (PPIase) 家族的成员。 PPIases 催化寡肽中脯氨酸亚胺肽键的顺反异构化，加速蛋白质的折叠。 所编码的蛋白质是一种环孢菌素结合蛋白，可能在环孢菌素 A 介导的免疫抑制中发挥作用。 该蛋白还可以与几种 HIV 蛋白相互作用，包括 p55 gag、Vpr 和衣壳蛋白，并且已被证明是形成传染性 HIV 病毒体所必需的。 已经报道了映射到不同染色体的多个假基因。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the peptidyl-prolyl cis …

2021年6月10日 · In this study, we carried out genome-wide analysis of PPIases in different Penicillium spp. and investigated their regulation by salt stress in a halotolerant strain of Penicillium oxalicum.

2024年12月25日 · PPIG (Peptidylprolyl Isomerase G) is a Protein Coding gene. Diseases associated with PPIG include Febrile Seizures, Familial, 9 and Epilepsy, Idiopathic Generalized 11. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Infectious disease.

Peptidyl-prolyl isomerase (PPIase) catalyzes the interconversion of a specific Pro-imide bond between the cis and trans conformations. Two families of PPIases, cyclophilins and FKBPs, have been extensively studied because of their high affinity for immunosuppressive drugs in particular cyclosporine A and FK506.

2016年7月13日 · Peptidyl-proline isomerases (PPIases) are a chaperone superfamily comprising the FK506-binding proteins (FKBPs), cyclophilins, and parvulins. PPIases catalyze the cis/trans isomerization of proline, acting as a regulatory switch during folding, activation, and/or degradation of many proteins.

Peptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of …

Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis.

2022年8月26日 · Here, we demonstrate that the most ubiquitous peptidyl prolyl isomerase, peptidyl prolyl isomerase A (PPIA), concentrates inside liquid-like droplets formed by the Alzheimer’s disease-associated protein tau, as well as inside RNA-induced coacervates of a proline–arginine dipeptide repeat protein.

Peptidyl-prolyl cis-trans isomerases (PPI) catalyze cis-trans isomerization of imide bonds in peptides and proteins. This review summarizes the literature on the structure and functions of PPIs, their involvement in protein folding, and organization of PPI-containing receptors and membrane channels.

2015年1月1日 · Peptidyl-prolyl isomerase (PPIase) catalyzes the interconversion of a specific Pro-imide bond between the cis and trans conformations. Two families of PPIases, cyclophilins and FKBPs, have been extensively studied because of their high affinity for immunosuppressive drugs in particular cyclosporine A and FK506.