Phosphoramide is a chemical compound with the molecular formula O=P (NH2)3. It is a derivative of phosphoric acid in which each of the hydroxyl groups have been replaced with an amino group. In bulk, the compound is a white solid which is soluble in polar solvents. Phosphoramide arises from the reaction of phosphoryl chloride with ammonia.

Phosphoramides are a class of phosphorus compounds with the formula O=P (NR 2) 3-n (OH) n. They can be considered derivatives of phosphoric acid where OH groups have been replaced with an amino or R-substituted amino group.

2021年11月15日 · Vidarabine (ARA) was one of the earliest marine-related compounds to be used clinically for antiviral therapy, however, its fast metabolism is the main defect of this drug. To overcome this, we designed and synthesized a group of phosphamide-modified ARA compounds using ProTide technology.

Ethyl bromoacetate mediates a facile and efficient synthesis of primary phosphinamides from Ar 2 P (O)-H reagents with stable and readily available ammonium carbonate as an ammonia source under mild and simple conditions, without any metal catalyst or oxidant.

环磷酰胺为最常用的烷化剂类抗肿瘤药，进入体内后，在 肝微粒体酶 催化下分解释出烷化作用很强的氯乙基磷酰胺 (或称磷酰胺氮芥)，而对肿瘤细胞产生细胞毒作用，此外本品还具有显著免疫作用。 临床用于 恶性淋巴瘤， 多发性骨髓瘤，白血病、乳腺癌、卵巢癌、宫颈癌、 前列腺癌 、结肠癌、 支气管癌 、肺癌等，有一定疗效。 也可用于 类风湿关节炎 、 儿童肾病综合征 以及 自身免疫疾病 的治疗。 [1] 性状:本品为白色结晶或结晶性粉末。 药品类别:烷化剂类抗肿瘤药 药理毒 …

phosphamide (plural phosphamides) (organic chemistry) Any amide of a phosphonic acid (i.e. in which one of more OH groups have been replaced by -NH 2 etc)

Crystal structure of phosphoric triamide. Journal of the Chemical Society A: Inorganic, Physical, Theoretical (1966-1971) 1969;1969:1804-1812. Follow these links to do a live 2D search or do a live 3D search for this compound, sorted by annotation score.

Know about technical details of Phosphamide like: chemical name, chemistry structure, formulation, uses, toxicity, action, side effects and more at Pharmacompass.com.

CAS号查询致力于为化学行业用户免费提供phosphamide的CAS号、中文名称、英文名称相互转换服务,同时也包括phosphamide的性质、化学式、分子结构、密度、熔点、沸点等信息。

Inhibition of the elastase of Pseudomonas aeruginosa by N.alpha.-phosphoryl dipeptides and kinetics of spontaneous hydrolysis of the inhibitors.

A promising approach to the synthesis of phosphamide lipid constructions of cationic type on the basis of cyclophosphites and -amidophosphites is considered. The latter easily undergo oxidative decyclization under the action ofchlorine or bromine.

2024年1月1日 · In our present study, the P–N BDEs, substituent effects as well as structure-property relationships in phosphamide and phosphoramidate systems including DOPO-based FRs, diphenyl-phosphamide, phosphoramidate FRs and spirocyclic-bisphosphamide, bisphosphoramidate FRs, etc. were systematically investigated by using DFT.

2024年3月22日 · A type of modified nucleotide, deoxynucleotide γ-amidotriphosphates (dNTPγNH2s), exhibited around five times higher stability than dNTPs. These phosphamide nucleotides can be utilized by several DNA polymerases, and the amplification of a 10 kb DNA fragment through the polymerase chain reaction (PCR) can be

2020年1月17日 · As a demonstration, current studied axially chiral ortho -iodine substituted phosphamides could act as efficient chiral hypervalent iodine (III) catalysts for the asymmetric oxidative dearomatization of phenols.

In the present work we offer a new approach to application of this reaction in phospholipid synthesis. It includes synthesis of new phosphorylating reagents, unsymmetrical halophosphates, by halogenation of the simplest alkylene phosphites and amidophos-phites and subsequent reaction of the products with glycerol derivatives.

2023年11月20日 · Being chemically analogous to phosphine oxide, phosphamide can also be considered as a mediator for the phosphine-mediated reaction. Herein, an amorphous polymeric material consisting of phosphamide (−NH–P(O)) in the repeating unit (POP) has been prepared via condensation of tris(2-aminoethyl)amine (TREN) and phenyl phosphinic dichloride ...

The experiment involved an investigation into the action of O,O-dimethyl-S-(N-methyl-carbomoilmethyl)-dithiophosphate (phosphamide), used at the level of the liminal dose (4 mg/kg) and in a concentration of 1.9 mg/m3, as compared with the effect of 1/2 of the liminal dose and 1/2 of the thereshold c …

Phosphoramidates (P-N) are a class of organophosphorus compounds known for the presence of a single covalent bond between the tetracoordinate P (V) atom and N (III) atom. There are generally three types of phosphoroamidates, which are distinguished according to the substitution on the P and N atoms (Figure 1) [1]. Figure 1.

2023年5月6日 · The presence of phosphamide functionality (NH─P═O) in 2 can be confirmed by its characteristic Raman vibration at 999 cm –1 with expected P–N and P═O bonds distances from the single-crystal X-ray structure.