Emerging evidence suggests that saikosaponins have many pharmacological effects, including sedation, anticonvulsant, antipyretic, antiviral, immunity, anti-inflammation, antitumor properties, protecting liver and kidney and so on.

A broad spectrum of in vitro and in vivo research has proved that Radix Bupleuri extracts, saikosaponin a, saikosaponin d, saikosaponin c, and saikosaponin b 2, exhibit evident anti-inflammatory, antitumor, antiviral, anti-allergic, immunoregulation, and neuroregulation activities mainly through NF-κB, MAPK or other pathways. 15 clinical ...

Saikosaponin A is the main active ingredient in Bupleurum chinense, which can regulate lipid metabolism and promote cholesterol efflux in early atherosclerosis. In addition, Saikosaponin A may also serve as a potential peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, significantly promoting the expression of PPAR-γ.

2024年9月1日 · Saikosaponin A (SSA), a triterpenoid saponin derived from Radix Bupleuri, is a prominent bioactive compound known for its therapeutic potential. Importantly, SSA is recognized for its widespread use in contemporary Chinese medicinal formulations.

Saikosaponins are triterpene saponin glycosides derived from the traditional oriental medicinal plant, Bupleuri Radix, which has been widely used for its antioxidant, anti-inflammatory, antipyretic, and antihepatotoxic effects in the treatment of influenza, fever, hepatitis, malaria, and menstrual disorders [1 – 5].

2024年11月30日 · Saikosaponins (SSs) are one of the major active components of radix bupleurum and a triterpenoid saponin extracted only from Bupleurum plants, known for their diverse pharmacological characteristics [5]. Saikosaponins can be further categorized as Saikosaponin A, B1, B2, B3, B4, C, D, E, F, G, H, and I [6].

Saikosaponin A | C42H68O13 | CID 167928 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2023年7月5日 · Key findings: Numerous studies have shown that Saikosaponin A exerts anti-inflammatory effects by modulating cytokine and reactive oxygen species (ROS) production and lipid metabolism. Moreover, saikosaponin D exerts antitumor effects by inhibiting cell proliferation and inducing apoptosis and autophagy, and the antiviral mechanisms of SSs ...

2024年7月4日 · Given its multi-faceted anti-tumor roles, saikosaponin D offers promising potential in anti-tumor therapy. This paper reviews recent studies on its anti-tumor effects, aiming to furnish new theoretical insights for clinical cancer treatments. In recent years, cancer incidence and mortality rates have witnessed a marked increase.

Saikosaponin A is a triterpene saponin isolated from the widely used TCM Radix Bupleuri [132], which has a variety of pharmacological effects and can be used to treat a variety of diseases, including immune system disorders [133].