Swainsonine - Wikipedia
Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. [1] . As a toxin in locoweed (likely its primary toxin [2]) it also is a significant cause of economic losses in livestock industries, particularly in North America.
Swainsonine: a new antineoplastic immunomodulator. - PubMed …
Swainsonine, an indolizidine alkaloid with immunomodulatory activity, has been found to be effective in inhibiting metastatic dissemination and growth of primary tumors of both murine and human origins.
Swainsonine | C8H15NO3 | CID 51683 - PubChem
2009年7月7日 · An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
Swainsonine - an overview | ScienceDirect Topics
Swainsonine is a synthetic salt form of a plant toxin derived from a plant called locoweed. It is a competitive inhibitor of Golgi α-mannosidase II and affects the structure of carbohydrates, which can inhibit metastasis and impact the function of lymphocytes.
Unveiling of Swainsonine Biosynthesis via a Multibranched …
2020年8月7日 · The indolizidine alkaloid swainsonine (SW) is a deadly mycotoxin to livestock that can be produced by different plant-associated fungi, including the endophytic entomopathogenic fungi Metarhizium species. The SW biosynthetic gene cluster has been identified but the genetic mechanism of SW biosynthesis remains obscure.
Swainsonine - an overview | ScienceDirect Topics
Swainsonine is known for its immunomodulator potential, and it is found in several species of the Fabaceae and Convolvulaceae families [49]. Castanospermine is a related compound originally discovered in the seeds of Castanospermum austral [50] .
Swainsonine - an overview | ScienceDirect Topics
Swainsonine is an indolizidine alkaloid produced by certain species of the plants genera Astragalus, Oxytropis, and Swainsona. You might find these chapters and articles relevant to this topic. Biochemistry of hemlock (Conium maculatum L.) alkaloids and their acute and chronic toxicity in livestock. A review. T.A López, ...
Swainsonine-Containing Plants and Their Relationship to …
2014年4月24日 · Swainsonine, an indolizidine alkaloid with significant physiological activity, is an α-mannosidase and mannosidase II inhibitor that alters glycoprotein processing and causes lysosomal storage disease. Swainsonine is present in a number of plant species worldwide and causes severe toxicosis in livestock grazing these plants.
The Genome of Undifilum oxytropis Provides Insights into Swainsonine …
2016年8月1日 · Undifilum oxytropis is a fungal endophyte of locoweeds. It produces swainsonine, which is the principal toxic ingredient of locoweeds. However, the genes, pathways and mechanisms of swainsonine...
Swainsonine: an inhibitor of glycoprotein processing - PMC
Swainsonine, an indolizidine alkaloid, inhibits the processing of asparagine-linked glycoproteins in both cell-free extracts and animal cells in culture.