T-cell large granular lymphocyte leukemia is a rare cancer of a type of white blood cells called lymphocytes. T-cell large granular lymphocyte leukemia causes a slow increase in white blood cells called T lymphocytes, or T cells, which originate in the lymph system and bone marrow and help to fight infection.

2022年9月3日 · Large granular lymphocytic leukemia (LGL) is a rare type of chronic leukemia that affects white blood cells known as lymphocytes. There are three types of large granular lymphocytic leukemia. Two types grow slowly and act like …

There are two types of LGL leukemia: T-cell (T-LGL) and natural killer cell (NK-LGL). Each type may be chronic (slow-growing) or aggressive (fast-growing). The frequency of T-cell and NK-cell LGL leukemia ranges from 2 to 5 percent of chronic lymphoproliferative diseases.

T-cell large granular lymphocytic leukemia (T-LGLL) is a heterogenuous disorder characterized by a persistent (> 6 months) increase in the number of peripheral blood large granular lymphocyte s (LGLs) without a clearly identified cause. Chronic lymphoproliferative disorder of NK cell s (CLPD-NKs) are rare and heterogenuous.

Understanding how leukemic T-LGL persists can aid in the development of future immunosuppressive therapies. In this review, we summarize the diagnosis and current standard of therapy for T-LGL leukemia, as well as recent advances in clinical trials. Keywords: T-cell large granular lymphocyte leukemia, Diagnosis, Treatment.

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Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood. [1] It is divided in two main categories: T-cell LGL leukemia (T-LGLL) and natural-killer (NK)-cell LGL leukemia (NK-LGLL).

大颗粒淋巴细胞（LGL）白血病于1985年被首次描述为一类累及血液、骨髓、肝脾的克隆性疾病，以胞质中含有粗大嗜天青颗粒的淋巴细胞为特征。 LGLL的诊断标准为外周血LGL>2×10 9 /L持续6个月以上。 但如果能确定淋巴细胞为单克隆或疾病进展迅速，即使LGL<2×10 9 /L，持续时间未满6个月，也可以诊断LGLL [2]。 其中CD3 + T-LGLL约占LGLL的85% [2]。

Large Granular Lymphocyte (LGL) leukemia is at the intersection of a clonal lymphoproliferative disease, chronic inflammation, and autoimmunity. The association between rheumatoid arthritis (RA) and the spectrum of Felty’s Syndrome is well-known.

We evaluated the clinical course and treatment response of 60 consecutive patients with T-LGLL to evaluate clinical outcomes and future potential treatment directions. Impaired overall survival was noted among male patients, patients with elevated lactate dehydrogenase, and those without rheumatoid arthritis.