How regulatory T cells work | Nature Reviews Immunology
Regulatory T (T Reg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity and limiting chronic inflammatory diseases. However, they also limit beneficial responses by...
Regulatory T cells: Purpose, Function & Development - Cleveland Clinic
Regulatory T cells, or Tregs, are white blood cells that play a key role in regulating your immune system. Tregs control your body’s immune response to keep it from over-reacting to harmful invaders known as antigens .
How do Regulatory T Cells Work? - PMC - PubMed Central (PMC)
Suggested functions for Treg cells include: prevention of autoimmune diseases by maintaining self-tolerance; suppression of allergy, asthma and pathogen-induced immunopathology; feto-maternal tolerance; and oral tolerance.
Principles of regulatory T cell function: Immunity - Cell Press
2023年2月14日 · Dikiy and Rudensky review the mechanisms by which Treg cells prevent autoimmunity, mitigate inflammation, and support tissue function. They highlight how Treg cells identify cellular targets, localize to appropriate sites, become activated, and prevent intrinsic inflammatory responses in relation to the efficacy of their seemingly redundant ...
Regulatory T Cells (Tregs) | British Society for Immunology
As the name suggests regulatory T cells (also called Tregs) are T cells which have a role in regulating or suppressing other cells in the immune system. Tregs control the immune response to self and foreign particles (antigens) and help prevent autoimmune disease. Tregs produced by a normal thymus are termed ‘natural’.
Regulatory T Cells and Immune Tolerance - Cell Press
2008年5月30日 · Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery.
Regulatory T cells (TREG) and their roles in immune system ... - PubMed
Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress immune response, thereby maintaining homeostasis and self-tolerance. It has been shown that Tregs are able to inhibit T cell proliferation and cytokine production and play a …
The regulation and differentiation of regulatory T cells and their ...
2024年2月19日 · In this Review, we discuss the origins of T reg cells in the periphery and the multilayered mechanisms by which T reg cells are induced, as well as the FOXP3-dependent and FOXP3-independent...
The development and function of regulatory T cells - PMC
Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance. There are two types of Tregs: natural Tregs, which develop in the thymus, and induced Tregs, which are derived from naive CD4 + T cells in the periphery. Tregs utilize a variety of mechanisms to suppress the immune response.
Regulatory T cells function in established systemic ... - Nature
2021年8月23日 · Thus, T reg cells are functional in settings of established broad-spectrum systemic inflammation and are capable of affording sustained reset of immune homeostasis. T reg cells expressing the...