Highly conserved α- and β-tubulin heterodimers assemble into dynamic microtubules and perform multiple important cellular functions such as structural support, pathway for transport and force generation in cell division. Tubulin exists in different ...

Feb 6, 2020 · The tubulin proteins α- and β polymerize into long chains or filaments that form microtubules, an essential element of the eukaryotic cytoskeleton.

Oct 22, 2019 · This special issue "Tubulin: Structure, Functions and Roles in Disease" contains eight articles, five of which are original research papers and three are review papers that cover diverse areas of tubulin biology and functions under normal and pathological conditions.

In contrast to intermediate filaments, which are composed of a variety of different fibrous proteins, microtubules are composed of a single type of globular protein, called tubulin. Tubulin is a dimer consisting of two closely related 55-kd polypeptides, α-tubulin and β-tubulin.

Jul 5, 2024 · Tubulin is a globular protein that forms the building blocks of microtubules, which are integral components of the cytoskeleton. The protein exists primarily in two forms, alpha-tubulin and beta-tubulin, which dimerize to create a heterodimer.

Oct 22, 2019 · This special issue “Tubulin: Structure, Functions and Roles in Disease” contains eight articles, five of which are original research papers and three are review papers that cover diverse areas of tubulin biology and functions under normal and pathological conditions.

Feb 27, 2020 · We discuss how tubulin isotypes and post-translational modifications control microtubule behaviour at the molecular level and how this translates into physiological functions at the cellular and...

The diversity of tubulin genes (isotypes) and the complexity of tubulin PTMs have led to the proposal of the term “tubulin code” (Verhey and Gaertig, 2007; Wehenkel and Janke, 2014), in analogy to the previously coined histone code (Jenuwein and Allis, 2001).

Tubulin is a highly conserved, negatively charged protein that is found in essentially all eukaryotic cells. These properties ensure that isolation protocols successful in one system will likely work, with a few modifications, in most systems.

Tubulin is the major protein in the mammalian brain that plays a crucial role in maintaining the integrity of microtubules, which are essential organelles for neurite outgrowth, axoplasmic transport, and synaptic function in the nervous system. AI generated definition based on: Selected Topics from Neurochemistry, 1985