Aβ-aggregation-generated blue autofluorescence illuminates senile ...
2023年7月7日 · In summary, we conclude that Aβ-aggregation-generated blue autofluorescence is an excellent amyloid pathology marker in the senile plaques, blood and vascular pathologies in the Alzheimer′s...
Aβ-Aggregation-Generated Blue Autofluorescence Illuminates Senile ...
2024年2月12日 · The results showed that the Aβ peptide aggregation directly contributes to the senile plaque blue autofluorescence and the amyloid blue autofluorescence may be a valuable label-free marker for both senile plaques and a spectrum of important blood and vascular amyloid pathologies in AD.
Senile plaques in Alzheimer's disease arise from Aβ‐ and …
2022年11月30日 · Senile plaques are a pathological hallmark of Alzheimer's disease (AD), yet the mechanism underlying their generation remains unknown. Beta-amyloid peptide (Aβ) is a major component of senile plaqu...
Re-evaluating the nuclear staining on pathological sections in ...
2023年3月24日 · We did detailed studies on the senile plaque blue autofluorescence and found that senile plaque blue autofluorescence could be easily mistaken as nuclear staining. The blue "nuclear" staining...
Senile plaques in Alzheimer’s disease arise from Aβ and Cathepsin …
The mechanism governing senile plaque generation in Alzheimer's disease (AD) remains intensively debated. We analyzed AD brain tissues with histochemistry, immunohistochemistry and fluorescence...
Neuroleptic sensitivity in patients with senile dementia of Lewy …
1992年9月9日 · CONCLUSIONS--Severe, and often fatal, neuroleptic sensitivity may occur in elderly patients with confusion, dementia, or behavioural disturbance. Its occurrence may indicate senile dementia of Lewy body type and this feature has been included in clinical diagnostic criteria for this type of dementia.
Efficacy of rivastigmine in dementia with Lewy bodies: a …
2000年12月16日 · Rivastigmine is a cholinesterase inhibitor of the carbamate type and is symptomatically effective and safe in patients with mild to moderately-severe Alzheimer's disease at a dose of 6–12 mg daily. 14,15.
Risk Factors Associated with Senile Dementia of the
1986年9月1日 · Significant cognitive impairment affects approximately 15 percent of the U.S. population over age 65. The most prevalent form of irreversible dementia is senile dementia of the Alzheimer’s type (SDAT), which accounts for at least 50 percent of nursing home admissions and roughly 10 billion dollars a year in health care costs.
Neuroleptic sensitivity in patients with senile dementia of
1992年9月19日 · Severe, and often fatal, neuroleptic sensitivity may occur in elderly patients with confusion, dementia, or behavioural disturbance. Its occurrence may indicate senile dementia of Lewy body type and this feature has been included in …
Polychlorinated Biphenyls and Neurodegenerative Disease …
Noncerebrovascular dementia was defined as ICD-9 code 331.0 (Alzheimer disease), ICD-9 codes 290.0–290.3 (senile and presenile dementia), ICD-8 codes 290.0–290.1 (senile and presenile dementia), and ICD-7 codes 304–305 (senile and presenile psychoses, including Alzheimer disease).