A metastasis map of human cancer cell lines | Nature
2020年12月10日 · Here we introduce an in vivo barcoding strategy that is capable of determining the metastatic potential of human cancer cell lines in mouse xenografts at scale.
《Nature》：首张“癌症转移图谱”问世！揭秘人体癌细胞转移规 …
论文《A metastasis map of human cancer cell lines》发表在《Nature》上。. 该项研究荣登新一期《Nature》封面. 摘要： 大多数癌症死亡的原因是转移，但由于体内模型的复杂性，大规模转移研究一直不切实际。. 在这里，我们介绍了一种体内条形码策略，该策略能够在小鼠 ...
Abstract NG10: A metastasis map of human cancer cell lines
2021年7月1日 · We created a first-generation Metastasis Map (MetMap) that reveals organ-specific patterns of metastasis and allows relating those patterns to clinical and genomic features. We demonstrated the utility of MetMap by exploring the molecular basis of breast cancers capable of metastasizing to the brain - a principal cause of death in these patients.
A metastasis map of human cancer cell lines - DepMap
We created a first-generation metastasis map (MetMap) that reveals organ-specific patterns of metastasis, enabling these patterns to be associated with clinical and genomic features. We demonstrate the utility of MetMap by investigating the molecular basis of breast cancers capable of metastasizing to the brain—a principal cause of death in ...
A metastasis map of human cancer cell lines | Golub Lab
2021年5月10日 · We created a first-generation metastasis map (MetMap) that reveals organ-specific patterns of metastasis, enabling these patterns to be associated with clinical and genomic features. We demonstrate the utility of MetMap by investigating the molecular basis of breast cancers capable of metastasizing to the brain-a principal cause of death in ...
A metastasis map of human cancer cell lines - NASA/ADS
We created a first-generation metastasis map (MetMap) that reveals organ-specific patterns of metastasis, enabling these patterns to be associated with clinical and genomic features. We demonstrate the utility of MetMap by investigating the molecular basis of breast cancers capable of metastasizing to the brain—a principal cause of death in ...
A metastasis map of human cancer cell lines - Yonsei University
We validated the robustness, scalability and reproducibility of the method and applied it to 500 cell lines 1,2 spanning 21 types of solid tumour. We created a first-generation metastasis map (MetMap) that reveals organ-specific patterns of metastasis, enabling these patterns to be associated with clinical and genomic features.
A metastasis map of human cancer cell lines - Semantic Scholar
2020年12月1日 · A method in which pooled barcoded human cancer cell lines are injected into a mouse xenograft model enables simultaneous mapping of the metastatic potential of multiple cell lines, and shows that breast cancer cells that metastasize to …
A metastasis map of human cancer cell lines - IDEAS/RePEc
We created a first-generation metastasis map (MetMap) that reveals organ-specific patterns of metastasis, enabling these patterns to be associated with clinical and genomic features. We demonstrate the utility of MetMap by investigating the molecular basis of breast cancers capable of metastasizing to the brain—a principal cause of death in ...
A metastasis map of human cancer cell lines
A metastasis map of human cancer cell lines . View/ Open s41586-020-2969-2.pdf (14.94Mb)