关于细胞骨架的二三事（一） - 知乎 - 知乎专栏
2021年12月29日 · 细胞骨架常见结构：lamellipodia（薄片层）, filopodia（丝状伪足）, stress fiber（应力纤维）, cell rear（尾部） , Actin bundle. 接下来我们就一个一个慢慢聊聊。. 细胞的生长，分裂，迁移，各种动态变化都是伴随着细胞骨架的实时变化，如图就是一个细胞的迁移时细胞 ...
Actin bundle architecture and mechanics regulate myosin II …
2021年5月18日 · By using simulation and in vitro reconstitution, we demonstrate that the actin bundle architecture (interfilament spacing and filament polarity) and cross-linker mechanics impact the duration, direction, and magnitude of myosin-based force generation.
Regulation of Actin Bundle Mechanics and Structure by ... - PubMed
This review highlights the effects of macromolecular crowding, cation interactions, and actin-crosslinking proteins on actin bundle organization, structure, and mechanics. Understanding these mechanisms is important in determining in vivo …
Structure and Organization of Actin Filaments
Individual actin filaments are assembled into two general types of structures, called actin bundles and actin networks, which play different roles in the cell (Figure 11.6). In bundles, the actin filaments are crosslinked into closely packed parallel arrays.
Regulation of Actin Bundle Mechanics and Structure by …
2021年5月26日 · This review highlights the effects of macromolecular crowding, cation interactions, and actin-crosslinking proteins on actin bundle organization, structure, and mechanics. Understanding these mechanisms is important in determining in vivo actin biophysics and providing insights into cell physiology.
Crowding tunes the organization and mechanics of actin bundles …
Abstract. Fascin and α-actinin form higher-ordered actin bundles that mediate numerous cellular processes including cell morphogenesis and movement. While it is understood crosslinked bundle formation occurs in crowded cytoplasm, how crowding affects the bundling activities of the two crosslinking proteins is not known.
The Structure, Function, and Assembly of Actin Filament Bundles
1997年1月1日 · Actin bundles are formed when actin filaments are cross-linked into arrays with long axes of filaments parallel to each other. Actin bundles are large rigid structures that form in diverse cell types across eukaryotes to serve specific biological functions.
Structural basis of actin filament assembly and aging | Nature
2022年10月26日 · Cryo-electron microscopy structures of skeletal F-actin show solvent-driven rearrangements governing actin filament assembly and aging with potential application in design of drugs and small ...
Actin Bundles Dynamics and Architecture - MDPI
2023年2月28日 · Actin bundles are the main components of several complex cell structures (both stable and transient), such as microvilli, stereocilia, filopodia, and stress fibers. While all these structures are made up of packed actin bundles, they differ considerably in their molecular composition, dynamic nature, and biogenesis .
Actin-binding proteins sensitively mediate F-actin bundle …
2006年8月20日 · Bundles of filamentous actin (F-actin) form primary structural components of a broad range of cytoskeletal processes including filopodia, sensory hair cell bristles and microvilli....
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