Human Adenovirus 5 - an overview | ScienceDirect Topics
The DNA virus, human adenovirus 5 (Ad5), expresses small E1A (e1a) and large E1A proteins that coordinate the regulation of different sets of viral promoters, activate viral genes, and reprogram the host environment to achieve efficient viral replication. e1a is an oncogene that derepresses genes that drive G1 arrested cells into S phase [52 ...
Human Adenovirus Type 5 Infection Leads to Nuclear Envelope ... - PubMed
2021年12月2日 · The human adenovirus type 5 (HAdV5) infects epithelial cells of the upper and lower respiratory tract. The virus causes lysis of infected cells and thus enables spread of progeny virions to neighboring cells for the next round of infection.
Human Adenovirus 5 - an overview | ScienceDirect Topics
For historical reasons and because of its extended use in the viral vector field, human adenovirus type 5 (HAdV-C5) is the best characterized member of the adenovirus family. The structure of the HAdV-C5 virion was solved by cryo-electron microscopy (cryo-EM) at 3.5 Å resolution in 2010, in an impressive achievement given the size and ...
腺病毒 - 百度百科
腺病毒(adenovirus)是一种没有包膜的直径为70～90 nm的颗粒，由252个壳粒呈20面体排列构成。 每个壳粒的直径为7～9 nm。 衣壳里是线状双链DNA分子，约含30-47kb，两端各有长约100 bp的反向重复序列。
Addgene: Adenovirus Guide
There are 57 accepted human adenovirus types, and most adenoviral vectors are based on Ad5. Ad5-based vectors use the Coxsackie-Adenovirus Receptor (CAR) to enter cells. Recombinant adenovirus has two genes deleted: E1 and E3.
Human Adenovirus 5 - an overview | ScienceDirect Topics
Human adenovirus 5 (Ad5 together with Ad2 belong to the species C of the family Adenoviridae) is a non-enveloped virus with stable double-stranded linear DNA genome (≈36 kilobase pairs in length), which shows a low rate of spontaneous mutagenesis (1.3 × 10−7 per base per cell infection cycle) (Risso-Ballester et al., 2016).
Human Adenovirus Type 5 Infection Leads to Nuclear Envelope ...
2021年12月2日 · The human adenovirus type 5 (HAdV5) infects epithelial cells of the upper and lower respiratory tract. The virus causes lysis of infected cells and thus enables spread of progeny virions to neighboring cells for the next round of infection.
Adenovirus core protein V reinforces the capsid and enhances …
2023年4月7日 · Inside the human adenovirus type 5 (Ad5) capsid, the 36-kbp double-stranded DNA (dsDNA) genome is bound to positively charged viral proteins that constitute ∼50% of the core molecular weight: 150 copies of protein V (41 kDa), 500 to 800 copies of protein VII (22 kDa), and 100 to 300 copies of protein μ (9 kDa) (7–9).
Adenovirus-5 E1A: paradox and paradigm - Nature
2002年6月1日 · The proteins that are encoded by early region 1A (E1A) of human adenovirus type 5 (adenovirus-5) activate viral transcription and re-programme cellular gene expression in the infected cell,...
Recombinant human adenovirus type 5 promotes anti-tumor
2024年7月19日 · Recombinant human type 5 adenovirus (H101) is an oncolytic virus used to treat nasopharyngeal carcinoma. Owing to the deletion of the E1B-55kD and E3 regions, H101 is believed to selectively...