Alveolar cell fate selection and lifelong maintenance of AT2 cells …
2022年11月21日 · Here the authors show that FGF signaling initiates alveolus development in mouse lung by inducing AT2 fate and a secondary signal for AT1 fate, and continuously maintains AT2 cells throughout...
Tracing the origin of alveolar stem cells in lung repair ... - Cell Press
2024年5月9日 · Our lineage tracing data suggest that AT1 cells do not contribute to AT2 cells during lung homeostasis, injury, and repair. For club cells, BASCs, and AT2 cells, we achieved simultaneous and specific labeling of these three cell populations with distinct genetic reporters in the same individual mouse.
Alveolar type 2 progenitor cells for lung injury repair | Cell …
2019年2月8日 · Alveolar type 2 progenitor cells (AT2) seem closest to clinical translation, specifying the evidence that AT2 may satisfactorily control the immune response to...
Type II alveolar cell MHCII improves respiratory viral disease …
2021年6月28日 · Type II alveolar cells (AT2s) are critical for basic respiratory homeostasis and tissue repair after lung injury. Prior studies indicate that AT2s also express...
Lung Stem Cell Biology and the AT2 Cell: a Clear and Present …
2012年12月20日 · The alveolar type (AT) 2 pneumocyte (hereafter AT2 cell) is an endodermally derived, multifunctional, polarized epithelial cell spatially restricted to the distal mammalian adult lung .
Alveolar epithelial cell fate is maintained in a spatially restricted ...
2021年5月11日 · Alveolar epithelial type 2 (AT2) cells integrate signals from multiple molecular pathways to proliferate and differentiate to drive regeneration of the lung alveolus. Utilizing in vivo genetic and ex vivo organoid models, we investigated the role of Fgfr2 signaling in AT2 cells across the lifespan a ….
Characterization of perivascular alveolar epithelial stem ... - Cell …
Following inflammatory lung injury, we observed an increase in adventitial fibroblast-like cells, HA, and CD44 high AT2 cells across the lung parenchyma. Notably, CD44 high AT2 cells uniquely express intrinsic immunity-related signaling molecules, even in …
Alveolar cell fate selection and lifelong maintenance of AT2 cells …
a Expression of Fgfr2 and the four other receptor genes most selectively expressed in alveolar type 2 (AT2) cell lineage (“Receptors”) from single-cell RNA sequencing (scRNAseq) analysis of distal (alveolar) epithelial cells from embryonic day 18.5 (e18.5) mouse lung. Cells (columns) are arranged in developmental pseudotime (BP, bipotent …
Inflammatory Signals Induce AT2 Cell-Derived Damage …
2020年9月3日 · Here we focused on how inflammatory stimuli direct the cell fate behavior of AT2 stem cells during lung injury repair. Our data reveal the detailed stepwise differentiation trajectories of AT2 cells, which are regulated by IL-1β-mediated inflammatory signals during the regeneration process.
Heterogeneous groups of alveolar type II cells in lung ... - PubMed
2020年12月1日 · The revelation of AT2 heterogeneity has brought new insights into the role of AT2 cells in various lung disease settings and potentiates the finding of more therapeutics targets. In this mini review, we discuss the recently identified subpopulations of AT2 cells and their functions under steady-state, postinjury, and pathological conditions.