Bone Morphogenetic Protein (BMP) signaling in development …
2014年9月1日 · Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially discovered for their ability to induce bone formation, BMPs are …
TGF-β/BMP signaling and other molecular events: regulation of
2015年4月14日 · Phosphorylation of TGF-β (I/II) or BMP receptors activates intracellular downstream Smads, the transducer of TGF-β/BMP signals. This signaling is modulated by various factors and pathways,...
The roles and regulatory mechanisms of TGF-β and BMP signaling …
2024年1月24日 · TGF-βs and BMPs transduce signals through SMAD-dependent and -independent pathways; specifically, they recruit different receptor heterotetramers and R-Smad complexes, resulting in unique...
Bone Morphogenetic Proteins - PMC
BMPs and the related “growth and differentiation factors” (GDFs) are members of the transforming growth factor β (TGF-β) family, and transduce their signals through type I and type II serine–threonine kinase receptors and their intracellular …
Bone Morphogenetic Protein (BMP) signaling in development …
Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects, highlighting the essential functions of BMPs. In this review, we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in ...
TGF-β and BMP Signaling in Osteoblast Differentiation and Bone ...
In this review, we will summarize novel discoveries from recent decades regarding the regulations of TGF-β/BMP signaling in bone as well as the different modes of cross-talk between TGF-β/BMP signaling and the signaling pathways of MAPK, Wnt, Hedgehog, Notch, and FGF.
BMP signalling in skeletal development, disease and repair
2016年2月19日 · In this Review, we describe BMP superfamily signalling in the context of skeletal development and joint morphogenesis, with the premise that the pathway is poised as a promising...
Bone morphogenetic protein signaling: the pathway and its
2024年2月7日 · We have learned that while the core BMP pathway is quite simple, composed of 3 components (ligand, receptor, and signal transducer), behind the versatility of this pathway lies multiple layers of regulation that ensures precise tissue-specific signaling output.
Making sense of BMP signaling complexity - Cell Press
2022年5月18日 · A striking example of cross-wired signaling complexity in mammals is the Bone Morphogenetic Protein (BMP) pathway, which comprises approximately ten major homodimeric ligand variants and four Type I and three Type II receptor subunits.
Functions of the bone morphogenetic protein signaling pathway …
2022年7月9日 · By binding to various receptor complexes, BMPs activates two major downstream signaling pathways: Smad-dependent and Smad-independent.
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