实战经验！盲肠结扎穿孔术构建小鼠脓毒症模型_文献解读_Elabscie…
Mar 20, 2024 · 盲肠结扎穿孔（Cecal ligation and puncture, CLP）模型是最接近于人类脓毒症机制的模型，被称为脓毒症模型的“金标准”。 该模型通过结扎并穿孔盲肠，使混有多种细菌的肠内 …
Sepsis modeling in mice: ligation length is a major severity …
Jul 18, 2016 · Our study suggests that the length of cecal ligation is a major severity factor in the mouse CLP model when needle size and the number of punctures are controlled. …
Cecal ligation puncture procedure - PubMed
May 7, 2011 · The most widely used clinical model is cecal ligation and puncture (CLP). The CLP model consists of the perforation of the cecum allowing the release of fecal material into the …
Mouse Models of Sepsis - PubMed
Basic Protocol 1 details a non-synchronous cecal ligation and puncture (CLP) model of sepsis, where mice are subjected to polymicrobial exposure through surgery at different time points …
Two murine models of sepsis: immunopathological differences …
Oct 24, 2023 · Endotoxic shock (ExSh) and cecal ligature and puncture (CLP) are models that induce sepsis. In this work, we investigated early immunologic and histopathologic changes …
小鼠脓毒症模型的建立和评价-【维普期刊官网】- 中文期刊服务平台
方法采用盲肠结扎穿孔法 (cecal ligation and puncture,CLP)诱导小鼠脓毒症,通过动物生存、术后小鼠载菌量、血常... 展开更多 目的建立小鼠脓毒症模型并进行评价,为研究脓毒症致病机制和开 …
Immunodesign of experimental sepsis by cecal ligation and puncture
Dec 11, 2008 · The model of CLP is widely used and known to closely mimic the pathophysiology of septic human patients. Accordingly, polymicrobial sepsis is associated with an early …
Multi-Organ Transcriptome Dynamics in a Mouse Model of Cecal …
Jun 3, 2021 · We used RNA sequencing to characterize transcriptional changes in the early phase of sepsis, at 6, 12, 24 hour time points in lung, kidney, liver, and heart tissues, in a …
Cecal ligation and puncture: the gold standard model for …
Apr 1, 2011 · Polymicrobial sepsis induced by cecal ligation and puncture (CLP) is the most frequently used model because it closely resembles the progression and characteristics of …
Mouse Models of Sepsis - Kannan - 2024 - Current Protocols
Mar 4, 2024 · Cecal ligation and puncture (CLP) is one such model that was first established in mice in 1983 (Baker et al., 1983). The CLP model captures some of the most important …