细胞毒性T淋巴细胞 - 百度百科
该试验测定被特定 抗原 攻击后抗原特异性CD8+T淋巴细胞的裂解或者引起的炎症反应。 用细胞毒性T淋巴细胞（CTL）测试细胞介导免疫需要成功的抗原呈递，以及随之产生的 细胞因子 、细胞接触依赖的信号转导来产生记忆T淋巴细胞，这是T细胞应答的基础。 CTL试验曾用于小鼠和大鼠，也用于大型动物模型，但标准的临床前评价试验模型还没有建立。 较好的用于CTL试验的抗原是活的流感病毒。 将选择的病毒通过鼻内感染的方式感染成年动物。 用已知数目的病毒隔夜培 …
Cytotoxic T cell - Wikipedia
A cytotoxic T cell (also known as T C, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8 + T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracellular pathogens (such as viruses or bacteria), or cells that are damaged in other ways.
CTL细胞毒性T细胞 (CD8+T细胞)是什么细胞-赛默飞 | Thermo …
细胞毒性T淋巴细胞（CTL细胞）通常称为CD8 + T细胞，是适应性免疫系统的关键组成部分，在免疫系统抵御病原体（如病毒、细菌和肿瘤）中发挥重要作用 [1]。 辅助性CD4 + T细胞（如 Th1 、Th2、Th9、 Th17 、Th22、 Tfh 和 Treg）是在胸腺中生成并表达αβ-T细胞受体或TCR，但与CD4 + T细胞不同的是它们的表面表达CD8 ，并且对MHC I类的外源性抗原反应。 Naive/静息CD8 + T细胞能够扩增和分化为细胞毒性效应细胞，监视机体并清除感染。 若缺失CD8 + T细胞 ，机体 …
CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...
Cytotoxic T Cell Overview | Thermo Fisher Scientific - US
What are cytotoxic T cells? Cytotoxic T lymphocytes (CTLs) often called CD8 + T cells, are a critical component of the adaptive immune system and play an important role in immune defense against intracellular pathogens such as viruses and bacteria and against tumors [1].
Cytotoxic T cells are able to efficiently eliminate cancer cells by ...
2021年9月1日 · Nature Communications - Cytotoxic CD8+ T lymphocytes (CTL) often fail to kill tumour cells in one-to-one interactions. Here the authors show that these sublethal interactions from multiple...
Interferon- γ derived from cytotoxic lymphocytes directly …
2017年6月1日 · Using live-cell imaging by prolonged time-lapse microscopy of primary effector CD8 T cells and antigen-expressing primary keratinocyte targets, we show that CD8 T-cell cytotoxic function and...
CD8 + T Cells: Foot Soldiers of the Immune System - PubMed …
In infected peripheral tissues, some effector CD8 + (CTL) T cells receive additional local signals including antigen, CD4 + T cell-derived IL-2, and innate cell-derived IL-27, and transiently acquire the ability to secrete IL-10 in a Blimp-1-dependent manner. CTL-derived IL-10 is critical to control local inflammation and tissue damage.
Immunometabolism of CD8 + T cell differentiation in cancer
2024年7月1日 · CD8 + cytotoxic T lymphocytes (CTLs) are central mediators of tumor immunity and immunotherapies. Upon tumor antigen recognition, CTLs differentiate from naive/memory-like toward terminally exhausted populations with more limited function against tumors.
CD8 + cytotoxic T lymphocytes in cancer immunotherapy: A review - PubMed
CD8 + cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immunerelated tolerance and immunosuppression within the tumor microenvironment (TME), with all favor adaptive immune-resistance.