Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets
2020年10月16日 · The abnormal metabolism of cancer cells is not merely a genetic mutation phenotype. It also directly affects tumor signal transduction pathways and cellular reactions. Based on this concept, the next-generation anticancer therapeutics examined in many studies and clinical trials target cancer-specific metabolic phenotypes.
Linking the genotypes and phenotypes of cancer cells in ...
2022年3月17日 · Cancer. Linking single-cell genomic or transcriptomic profiles to functional cellular characteristics, in particular time-varying phenotypic changes, could help unravel molecular mechanisms ...
The evolutionary theory of cancer: challenges and potential
2024年9月10日 · By measuring change in cancer cell phenotype (in vitro or in vivo) over different timescales and selective pressures, cancer biologists could quantify the degree of heritability of a...
Understanding the cancer cell phenotype beyond the limitations …
2015年9月29日 · Several cancer cells such as pancreatic ductal adenocarcinoma are largely resistant to chemotherapy and radiation because they maintain a cancer-stem-cell-like phenotype (high CD133 expression) . A stem-cell-like phenotype is associated with poor clinical-pathological outcomes because typical treatments (i.e. gemcitabine) are ineffective [ 110 ...
Understanding the cancer cell phenotype beyond the limitations of current omics analyses. Efforts to understand the mechanistic principles driving cancer metabolism and proliferation have been lately governed by genomic, transcriptomic and proteomic studies. This paper analyzes the caveats of these approaches.
Label-free morpho-molecular phenotyping of living cancer cells …
2024年6月29日 · Our multimodal imaging strategy rapidly distinguishes cancer phenotypes, limiting observations to a low number of pristine cells in culture. This synergistic dataset allows us to study...
Immune phenotypic linkage between colorectal cancer and ...
2022年4月11日 · Our study untangles how the phenotype of immune cells is orchestrated by cancer cells and host organs. At the major cell compartment level, mast cells fall into the M-type category as their phenotypes are mostly linked to malignancy, while DCs and NK cells are characterized as N-type since their phenotypes are shaped by the tissue niche.
Cancer cell plasticity: from cellular, molecular, and genetic ...
2024年2月8日 · Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance.
Cancer cell recognition – Mechanical phenotype - ScienceDirect
2012年12月1日 · Mechanical phenotype of cancerous cells. Atomic force microscopy. Cancer cell recognition. 1. Introduction. Recent studies of metastasis have created a large knowledgebase showing the importance of the mechanical properties involved in cancer transformation (Fritsch et al., 2010, Kumar and Weaver, 2009, Suresh, 2007a, Suresh, 2007b).
Cancer-associated fibroblast phenotypes are ... - Cell Press
2024年3月11日 · A better understanding of the cellular heterogeneity and interplay of cancer-associated fibroblasts (CAFs) within the tumor microenvironment will support the development of personalized therapies. We report a spatially resolved single-cell imaging mass cytometry (IMC) analysis of CAFs in a non-small cell lung cancer cohort of 1,070 patients.