The genomic landscape of 2,023 colorectal cancers | Nature
2024年8月7日 · Whole-genome sequencing of more than 2,000 colorectal carcinoma samples provides a highly detailed view of the genomic landscape of this cancer and identifies new driver mutations.
Molecular Origins of Cancer: Molecular Basis of Colorectal Cancer …
The most common type of genomic instability in colorectal cancer is chromosomal instability, which causes numerous changes in chromosomal copy number and structure. 7 Chromosomal instability is an efficient mechanism for causing the physical loss of a wild-type copy of a tumor-suppressor gene, such as APC, P53, and SMAD family member 4 (SMAD4 ...
Genetics of Colorectal Cancer (PDQ®) - NCI - National Cancer Institute
Hereditary colorectal cancer syndromes include Lynch syndrome and several polyposis syndromes (familial adenomatous polyposis, MUTYH-associated polyposis, juvenile polyposis syndrome, Peutz-Jeghers syndrome, and serrated polyposis syndrome).
Genetics of colorectal cancer - PMC - National Center for …
2014年5月28日 · The sequence of 102 human homologues from 96 known genes was decisive in the process of systematically identifying somatic mutations in genes with CIN potential in colorectal cancers. 11 somatic mutations have been identified over the five genes in a batch that included 132 cases of colorectal cancer.
Prognostic genome and transcriptome signatures in colorectal …
2024年8月7日 · Two distinct patterns of pathway co-mutations were observed, timing analyses identified nine early and three late driver gene mutations, and several signatures of colorectal-cancer-specific...
Genetic and biological hallmarks of colorectal cancer - PMC
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles.
Genetic and biological hallmarks of colorectal cancer
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to under ….
Systematic prioritization of functional variants and effector genes ...
2024年9月16日 · Genome-wide association studies of colorectal cancer (CRC) have identified 170 autosomal risk loci. However, for most of these, the functional variants and their target genes are unknown.
Detecting colorectal cancer using genetic and epigenetic …
Keywords: colorectal cancer, cancer, genetic biomarkers, epigenetic biomarkers, diagnostic biomarkers. INTRODUCTION. The estimated number of new cases of colorectal cancer (CRC) in 2018 was 1.85 million, representing about 10% of all cancers worldwide [1,2]. In 2018, 880,792 (9.2%) deaths were estimated to be attributable to CRC .
Colorectal cancer: Genetic alterations, novel biomarkers, current ...
2024年1月20日 · Colorectal cancer (CRC) is the third most commonly detected cancer with a serious global health issue. The rates for incidence and mortality for CRC are alarming, especially since the prognosis is abysmal when the CRC is diagnosed at an advanced or metastatic stage.