Nuclear structure in cancer cells | Nature Reviews Cancer
2004年9月1日 · There are characteristic differences in the nuclear architectures of cancer cells, compared with normal cells, and some anticancer treatments restore normal nuclear structure and function.
TUMOR CELL MORPHOLOGY - Comparative Oncology - NCBI Bookshelf
Morphologically, the cancerous cell is characterized by a large nucleus, having an irregular size and shape, the nucleoli are prominent, the cytoplasm is scarce and intensely colored or, on the contrary, is pale. The nucleus of neoplastic cells plays through its changes a main role in the assessment of tumor malignancy.
Extreme wrinkling of the nuclear lamina is a morphological marker of cancer
2024年12月2日 · Deep learning reveals the presence of extreme nuclear laminar wrinkling in cancer tissues, which is confirmed by Fourier analysis. These data support a model in which excess surface area in the...
Nuclear structure in cancer cells - PubMed
There are characteristic differences in the nuclear architectures of cancer cells, compared with normal cells, and some anticancer treatments restore normal nuclear structure and function. Advances in understanding nuclear structure have revealed insights into the process of malignant transformation and provide a basis for the development of ...
AI powered quantification of nuclear morphology in cancers …
2024年6月19日 · To assess whether nuHIFs differ between cancer types, we performed UMAP to compare the nuHIFs from cancer cells (Fig. 4a), fibroblasts (Fig. 4b), and lymphocytes (Fig. 4c) in BRCA, LUAD, and...
Nuclear Morphology and the Biology of Cancer Cells
2020年11月5日 · Two nuclei have pseudo-inclusions highly characteristic of papillary thyroid carcinoma. Nucleoli are prominent. c Normal crypts in the colon. Nuclei are small and mostly round. d High-grade colonic adenocarcinoma with large nuclei, highly irregular nuclear contours with folds and dents, and coarse chromatin. A mitotic figure is present.
Mechanical comparison of isolated and living breast cancer cell nuclei
2024年2月8日 · Here we systematically perform microrheological characterization of isolated and live cell nuclei obtained from the same breast cancer cell type. Viscous and elastic moduli of nuclei are measured and the results are modelled with viscoelastic spring-dashpot models.
Cancer nucleus: morphology and beyond - PubMed
Herein, the salient visual and subvisual morphological changes of cancer nuclei and their possible etiology and significance have been reviewed. There are many significant morphological alterations of a nucleus of cancer cell that are detectable by light microscopy on routine staining.
Melanoma Cells from Different Patients Differ in Their ... - MDPI
2024年11月12日 · Melanoma cells were more resistant to alpha radiation when compared with the response of another skin tumor, squamous cell carcinoma. The results are opening the way for alpha radiation treatment of melanoma with Diffusing alpha Radiation Therapy (Alpha DaRT).
Cancer Cells vs. Normal Cells: How Are They Different? - Verywell …
2023年4月21日 · Cancer cells are different from normal cells in how they grow, how they look, and what they do in the body. Even though cancer is common, there are actually many steps that a normal cell has to go through to become a cancerous cell. This article will explain how cancer cells and normal, healthy cells are different.