Recent Advances in the Enantioselective Synthesis of Chiral …
2021年10月22日 · Zheng and co-workers reported the first highly enantioselective synthesis of chiral β-aryl-γ-amino acid ester derivatives P112 via rhodium-catalyzed AH of γ-phthalimido-substituted acrylates using the BoPhoz-type ligand L53a .
Modular α-tertiary amino ester synthesis through cobalt …
2023年12月11日 · Now a cobalt-catalysed enantioselective aza-Barbier reaction of ketimines with various unactivated alkyl halides has been developed, forming diverse chiral α-tertiary amino esters with high...
Copper(I)-catalyzed asymmetric alkylation of α-imino-esters
2023年4月17日 · Control experiments indicate that the α-imino-ester is activated by a chiral copper (I)-phosphine complex through coordination, thus enabling facile deprotonation to provide a stabilized copper...
Enantioselective access to chiral aliphatic amines and ... - Nature
2021年5月13日 · Alkyl iodides containing ester, ether, thiophene, amide could be transformed to corresponding chiral alcohol derivatives (6d–6g) in 51–80% yields with 90–95% ee.
Cobalt-catalyzed enantioselective reductive addition of ketimine …
2024年9月26日 · We herein report an efficient construction of chiral α-tertiary amino acid derivatives containing cyclopropane fragments, which has been achieved via a cobalt-catalyzed asymmetric reductive addition of α-iminoesters with cyclopropyl chloride. This strategy enables the formation of these valuable motifs with broad functional group tolerance ...
Asymmetric Synthesis of N‐Substituted α‐Amino Esters from …
2021年2月8日 · N-Substituted α-amino esters are widely used as chiral intermediates in a range of pharmaceuticals. Here we report the enantioselective biocatalyic synthesis of N -substituted α-amino esters through the direct reductive coupling of α-ketoesters and amines employing sequence diverse metagenomic imine reductases (IREDs).
Stereodivergent access to non-natural α-amino acids via ... - Science
2024年8月29日 · Here, we report a Pd/Cu synergistic catalytic system that enables the stereodivergent synthesis of enantiopure non-natural α-quaternary amino acids bearing Z- and E-trisubstituted alkene moieties through a three-component assembly with aryl iodides, simple allenes, and α-amino acid–derived aldimine esters . Two chiral catalysts could exert ...
Modern Approaches to Synthetic Design of Chiral α-Tertiary
2022年3月10日 · The synthesis of enantiomerically pure methyl ester (R)-138b was performed by induced chirality using optically pure compound (1′S)-136a as a starting substrate. The relative configuration of the chiral centers in the intermediate compound (4 R ,1′ S )- 138a was determined by X-ray diffraction analysis of its racemic form.
Catalytic asymmetric direct α-alkylation of amino esters by …
Two types of BINOL-related chiral aldehydes were used as organocatalysts for the direct α-functionalization of N-unprotected amino esters. The first chiral aldehyde catalysed α-alkylation of 2-aminomalonates with 3-indolylmethanols via imine activation was reported.
Synthesis of Chiral α,β-Unsaturated γ-Amino Esters via Pd …
2017年8月3日 · A Pd-catalyzed asymmetric allylic amination of 4-substituted 2-acetoxybut-3-enoates with amines has been developed for the regiospecific synthesis of chiral α,β-unsaturated γ-amino esters. The desired chiral aminated products can be obtained in up to 98% yield, and 99% ee and can be conveniently transformed to chiral γ-amino acid/alcohol ...