Recent studies have begun to clarify the key mechanisms that link cilium assembly and disassembly to the cell cycle, and suggest new possibilities for therapeutic intervention.
The perennial organelle: assembly and disassembly of the primary cilium
2010年2月15日 · In this Commentary, we review the basic cellular mechanisms that underlie the early stages of cilium assembly and discuss how the cell cycle communicates with the ciliation program. A commonly held view is that ciliation occurs exclusively in cells that have exited the cell cycle and entered quiescence or differentiation.
Cilium structure, assembly, and disassembly regulated by the ...
2018年7月31日 · The cilium undergoes cycles of assembly and disassembly that are controlled by complex inter-relationships with the cytoskeleton. Microtubules form the core of the cilium, the axoneme, and are regulated by post-translational modifications, associated proteins, and microtubule dynamics.
Mechanism of ciliary disassembly | Cellular and Molecular
2016年2月11日 · Even though the presence of cilia is required for diverse functions, cilia can be removed through ciliary shortening or resorption that necessitates disassembly of the cilium, which occurs normally during cell cycle progression, …
The multifaceted roles of microtubule-associated proteins in the ...
2023年12月14日 · Here, we reviewed the architecture, composition and biogenesis of the primary cilium axoneme, as well as the various MAPs within the cilium, highlighting their mode of action and roles in the assembly, maintenance and disassembly of the axoneme.
Insights into the Regulation of Ciliary Disassembly - MDPI
2021年9月28日 · Based on the current literature, the molecular events regulating the process of cilia disassembly can be broadly categorized into (1) activation of AurA kinase and deacetylation of microtubules, (2) depolymerization of microtubules, and (3) ciliary membrane remodeling and inhibition of cilia assembly. 3.3.1.
Freeing the brake: Proliferation needs primary cilium to …
2020年9月21日 · While primary cilia are commonly found in differentiated or quiescent cells that are not cycling, disassembly of primary cilia may promote re-entry of these cells into the mitotic cycle, and support proliferation. Many cancer tissues or cancer-derived cells exhibit loss of …
L (IFT)ing the lid on cilium disassembly - The Company of Biologists
2022年11月14日 · The primary cilium is a microtubule-based organelle that performs sensory functions and is often referred to as the antenna of the cell. Cilium assembly and disassembly, in most cells, is tightly regulated in concert with the cell cycle.
Moonlighting of mitotic regulators in cilium disassembly
In this review, we show that a significant subset of key mitotic regulator proteins is moonlighting at the cilium, among which PLK1, AURKA, CDC20, and their regulators. Although ciliary assembly defects are linked to a variety of ciliopathies, ciliary disassembly defects are more often linked to brain development and tumour formation.
The cilium undergoes cycles of assembly and disassembly that are controlled by complex inter-relationships with the cytoskeleton. Microtubules form the core of the cilium, the axoneme, and are...