Clostridium perfringens alpha toxin - Wikipedia
Clostridium perfringens alpha toxin is a toxin produced by the bacterium Clostridium perfringens (C. perfringens) and is responsible for gas gangrene and myonecrosis in infected tissues. The toxin also possesses hemolytic activity.
Clostridium perfringens Infection - StatPearls - NCBI Bookshelf
2023年8月8日 · Pathophysiology from C. perfringens is through toxin-mediated tissue necrosis. Most toxins are pore-forming, causing an influx of solute and water, leading to cellular swelling and cell death. A hallmark of C. perfringens infection is the production of histotoxic gas through glucose fermentation. Toxins produced by C. perfringens
An update on the human and animal enteric pathogen Clostridium perfringens
2018年8月6日 · Clostridium perfringens, a rapid-growing pathogen known to secrete an arsenal of >20 virulent toxins, has been associated with intestinal diseases in both animals and humans throughout the past century. Recent advances in genomic analysis and experimental systems make it timely to re-visit this clinically and veterinary important pathogen.
Unveiling the pathogenic mechanisms of Clostridium perfringens toxins ...
The impact of C. perfringens infections is due in part to the bacterium’s potential to secrete multiple extracellular toxins, including alpha-toxin (CPA, cpa/plc gene), beta-toxin (CPB, cpb gene), epsilon-toxin (ETX, etx gene), iota-toxin (ITX, iap, and ibp binary genes), C. perfringens enterotoxin (CPE, cpe gene) and Necrotic enteritis B ...
Rethinking the role of alpha toxin in Clostridium perfringens ...
2017年2月16日 · The common assumption that, when causing intestinal disease, C. perfringens relies upon specific, plasmid-encoded toxins, was recently challenged by the finding that alpha toxin, which is produced by all C. perfringens strains, is essential for necro-haemorrhagic enteritis.
Toxin Plasmids of Clostridium perfringens | Microbiology and …
Virulence studies on chromosomal alpha-toxin and theta-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of alpha-toxin in Clostridium perfringens-mediated gas gangrene.
Clostridium perfringens α-Toxin Impairs Innate Immunity via …
2016年6月16日 · Clostridium perfringens infection interferes with replenishment of mature neutrophils in peripheral blood. Mice were injected intramuscularly with 1 × 10 7 colony-forming units (CFUs) of...
Role of Clostridium perfringens Alpha, Beta, Epsilon, and Iota Toxins …
2018年1月5日 · Virulence studies on chromosomal alpha-toxin and theta-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of alpha-toxin in Clostridium perfringens mediated gas gangrene. Mol Microbiol. 1995;15(2):191–202.
Sequencing of Clostridium perfringens toxin genes (cpa, etx, …
2021年7月1日 · Clostridium perfringens alpha-toxin is a key mediator of gas gangrene, which is a life-threatening infection that manifests as fever, pain, edema, myonecrosis, and gas production. Alpha-toxin possesses phospholipase C and sphingomyelinase activities.
Expression and purification of functional Clostridium perfringens alpha ...
2011年6月1日 · The alpha and epsilon toxins are 2 of the 4 major lethal toxins of the pathogen Clostridium perfringens. In this study, the expression of the epsilon toxin ( etx ) gene of C. perfringens was optimized by replacing rare codons with high-frequency codons, and the optimized gene was synthesized using overlapping PCR.