Functional genomics identify causal variant underlying the …
2023年2月4日 · CTSH knockout enhances the microglial phagocytosis of Aβ peptides. The CTSH gene was strongly expressed in glial cells in the brain according to the available single-cell sequencing data [55,...
Microglia development follows a stepwise program to regulate …
Global profiles of transcriptional states indicated that microglia development proceeds through three distinct temporal stages, which we define as early microglia (until embryonic day 14), pre-microglia (from embryonic day 14 to a few weeks after birth), and adult microglia (from a few weeks after birth onward).
The role of lysosomal cathepsins in neurodegeneration: …
2022年7月1日 · Particularly, alterations in lysosomal cathepsins CTSD, CTSB and CTSL can contribute to the pathogenesis of neurodegenerative diseases as seen for neuronal ceroid lipofuscinosis, synucleinopathies (Parkinson's disease, Dementia with Lewy Body and Multiple System Atrophy) as well as Alzheimer's and Huntington's disease.
Cathepsin S Regulates Antigen Processing and T Cell Activity in …
2020年4月23日 · CTSS activity is required to maintain pro-proliferative co-stimulatory signals between cancer cells and CD4 + T cells in GCs. Maintaining this communication is particularly important in the early phases of tumor development and in indolent tumors, where lymphoma cell proliferation depends on exogenous signals.
Stress-primed secretory autophagy promotes extracellular BDNF ...
2021年7月30日 · Among the nine detected cathepsins, only cathepsin H (CTSH; also identified as pro-CTSH) displayed a lower secretion from the WT than from Atg5 KO cells (Fig. 3c). For a better understanding of...
Human brain gene expression profiles of the cathepsin V and …
2018年7月1日 · To gain understanding of how the human brain expresses the cysteine (CTSV and CTSL) and serine (PCSK1 and PCSK2) protease pathway components, with exopeptidases (CPE, CTSH, and CPE), this study characterized the gene expression profiles of these proteases in 169 brain regions.
Extracellular matrix-associated gene expression in adult sensory neuron …
2013年1月30日 · The genes (Bsg, Cst3, Ctsb, Ctsd, Ctsl, Mmp14, Mnp19, Sparc) detected by the microarray screen as being relatively highly expressed are involved in the degradation of extracellular and intercellular proteins and could play a role in the response of the neurons to ECM cues in axonal growth [70].
Cysteine protease cathepsins in cardiovascular disease: from …
2018年4月20日 · CTSH and cholesteryl esterase modify LDL into a proatherogenic LDL particle that can induce macrophage foam cell formation and induce CTSH expression in a positive feedback loop 131.
Microglia rescue neurons from aggregate-induced neuronal …
2024年7月25日 · Microglia are crucial for maintaining brain health and neuron function. Here, we report that microglia establish connections with neurons using tunneling nanotubes (TNTs) in both physiological and pathological conditions. These TNTs facilitate the rapid exchange of organelles, vesicles, and proteins.
NKX2-1 Is Required in the Embryonic Septum for Cholinergic …
2017年8月15日 · The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of cholinergic ...