Drug-induced liver injury - UpToDate
2023年4月14日 · This topic will review the epidemiology, clinical manifestations, diagnosis, and management of drug-induced liver injury (DILI). The metabolism of drugs by the liver, the mechanisms by which drugs might injure the liver, and the use of medications in patients with liver disease are discussed separately.
Drug-Induced Hepatotoxicity - StatPearls - NCBI Bookshelf
2024年9月10日 · Drug-induced hepatotoxicity or drug-induced liver injury (DILI) is an acute or chronic response to a natural or manufactured compound. DILI can be classified based on clinical presentation (hepatocellular, cholestatic, or mixed), mechanism of hepatotoxicity, or histological appearance from a liver biopsy.
Drug, Herbal, and Dietary Supplement–induced Liver Injury
Confidently establishing a diagnosis of DILI is difficult because of the need to exclude more common competing causes of liver injury, the protean clinical manifestations from an individual agent, and the lack of a validated diagnostic biomarker.
Drug-induced Liver Injury - PMC - PubMed Central (PMC)
Drug-induced liver injury (DILI) is common and nearly all classes of medications can cause liver disease. Most cases of DILI are benign, and improve after drug withdrawal. It is important to recognize and remove the offending agent as quickly as possible to prevent the progression to chronic liver disease and/or acute liver failure.
DILIN | Drug Induced Liver Injury Network
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has established the Drug-Induced Liver Injury Network (DILIN) to collect and analyze cases of severe liver injury caused by prescription drugs, over-the-counter drugs, and alternative medicines, such as herbal products and supplements. Currently, DILIN is conducting 2 ...
Drug-induced liver injury: An overview and update - ScienceDirect
2023年4月1日 · Drug-induced liver injur (DILI) can be described as a liver injury caused by a variety of commonly used medications, herbal products or dietary supplements when all other etiologies of liver injury have been ruled out.
Drug-induced liver injury: a comprehensive review
2023年3月21日 · Drug-induced liver injury (DILI) remains a challenge in clinical practice and is still a diagnosis of exclusion. Although it has a low incidence amongst the general population, DILI accounts for most cases of acute liver failure with a fatality rate of up to 50%.
Immune-Mediated Drug-Induced Liver Injury: Immunogenetics …
Drug-induced Liver Injury (DILI) is defined by the presence of some degree of liver injury, commonly detected by the rise of liver-related enzymes in the blood, which can be causally related to a specific drug .
Drug-induced liver injury - PMC - PubMed Central (PMC)
Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF) in the western world. Excluding paracetamol overdose, nearly all DILI encountered in the clinical setting is idiosyncratic in nature because affected individuals represent only a small proportion of those treated with such drugs.
Drug-induced liver injury | Nature Reviews Disease Primers
2019年8月22日 · Drug-induced liver injury (DILI) is a term used to describe the unexpected harm that drugs in common use can cause to the liver, including damage to...
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