Double-Strand DNA Breaks | Learn Science at Scitable - Nature
The result is double-strand breaks (DSBs) in the chromosome. A DSB can also be caused by environmental exposure to irradiation, other chemical agents, or ultraviolet light (UV).
The mechanism of double-strand DNA break repair by the ... - PubMed
Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). The various causes of double-strand breaks (DSBs) result in a diverse chemistry of DNA ends that must be repair …
Double-strand DNA breaks - Latest research and news - Nature
2024年12月5日 · A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation.
DNA double-strand breaks: signaling, repair and the cancer
Here we describe recent progress in our understanding of how cells detect and signal the presence and repair of one particularly important form of DNA damage induced by ionizing radiation—the ...
DNA double-strand break signaling and human disorders
2010年11月5日 · Here, we highlight the recent progress in the signaling of DNA double-strand breaks, the major proteins and posttranslational modifications involved and the diseases and syndromes associated with impaired signaling of these breaks.
DNA double-strand break repair: Current Biology - Cell Press
1999年10月21日 · DNA double-strand breaks are repaired by means of two main mechanisms: nonhomologous end joining and homologous recombination (see Figure 1). Both mechanisms operate in all eukaryotic cells that have been examined but the relative contribution of each mechanism varies.
Origin, Recognition, Signaling and Repair of DNA Double-Strand Breaks ...
Double-strand breaks (DSBs) are of fundamental importance in many fields of biology. The incorrect repair of DSBs often results in chromosomal rearrangements, which are considered to be a major initiating factor in carcinogenesis.
Double‐strand DNA break repair: molecular mechanisms and …
Double-strand break (DSB), a significant DNA damage brought on by ionizing radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death.
How cells ensure correct repair of DNA double-strand breaks
2018年7月6日 · DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause senescence or cell death. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are the two major DNA-repair pathways.
Mapping the genetic landscape of DNA double-strand break repair
Failure to properly repair DNA double-strand breaks (DSBs) can result in genomic instability and cell death (Ciccia and Elledge, 2010).