Duke Viral Vector Core | Duke Viral Vector Core - Sites@Duke
Viral Vector Core at Duke University is a full service facility with extensive experience in the production of viral-based platforms for gene delivery including lentiviral vectors and adeno-associated vectors (AAV).
Collection-AAV | Duke Viral Vector Core
Trans-synaptic tracing tools are capable to assist in targeting neuronal subpopulations based on their synaptic connectivity to a downstream region.
Overview | Duke Viral Vector Core - Sites@Duke
AAV is commonly used in the preclinical and clinical settings due to its wide tropism, robust, long-term expression, and the low immunogenicity. Similar to the Lentiviral vector, the AAV can transduce non-dividing cells.
HOME | synthetic virology
We study the biology of Adeno-Associated Viruses (AAV) and use cutting edge molecular evolution strategies to discover new synthetic viral strains with improved function. In parallel, we study and engineer the AAV genome with a focus on molecular and regulatory elements, especially RNA transcription and splicing.
Kantor Lab | Duke Neurobiology
Viral Vector Core at Duke University is a full service facility with extensive experience in the production of viral-based platforms for gene delivery including HIV-1-based vectors, adeno-associated vectors (AAV) and Rabies Viruses.
StrideBio Announces a Multi-technology License and Master ... - Duke …
Our proprietary structure-inspired adeno-associated viral (AAV) vector engineering platform (STRIVE™) creates unique and differentiated capsids that overcome current limitations of first-generation gene therapies.
Cross-Species Evolution of New AAV Variants - Duke University
Efforts to optimize vector dosing or engineer improved vectors are confounded, at least in part, by differences in AAV biology across animal species. Here, we present a broadly applicable, cross-species evolution approach to tackle this challenge.
Evolving Adeno-Associated Virus for Editing T-Lymphocytes
To ameliorate this problem, we employed a capsid evolution from the AAV6 background to generate a murine T-lymphocyte tropic AAV variant dubbed Ark313. Ark313 is vastly superior to the parent serotype in transducing, gene editing and site-specific knockins in murine T-cells.
Cross-species evolution of a highly potent AAV variant ... - Scholars@Duke
2022年10月10日 · We discover a highly potent, cross-species compatible variant (AAV.cc47) that shows improved attributes benchmarked against AAV serotype 9 as evidenced by robust reporter and therapeutic gene expression, Cre recombination and CRISPR genome editing in normal and diseased mouse models.
Cross-species evolution of a highly potent AAV variant for
2022年10月10日 · We discover a highly potent, cross-species compatible variant (AAV.cc47) that shows improved attributes benchmarked against AAV serotype 9 as evidenced by robust reporter and therapeutic gene expression, Cre recombination and CRISPR genome editing in normal and diseased mouse models.