Ephrin-A2 regulates excitatory neuron differentiation and …
2017年9月18日 · Furthermore, ephrin-A2 participates in the creation of excitatory neurons by inhibiting apical progenitor proliferation in the ventricular zone, with the disruption of ephrin-A2 signaling...
Mechanisms of ephrin–Eph signalling in development ... - Nature
2016年1月21日 · Ephrin-A2 seems to act cell-autonomously in progenitor cells to inhibit neurogenesis, and it is under the control of EphA7, which is expressed by stem cells, astrocytes and ependymal cells 125.
Eph家族受体在机体生理和病理过程中作用机制的研究进展
摘要: 促红细胞生成素肝细胞激酶 (Erythropoietin-producing hepatocellular, Eph)受体家族作为目前已知最大的酪氨酸激酶受体家族，通过受体–配体结合，介导人类从胚胎发育到成人组织稳态诸多生物学功能的调节，参与机体各种免疫反应。. 研究发现，Eph受体在包括神经 ...
Disrupting the interaction between ephrin-A2 and EphA7 in the adult brain of wild-type mice disinhibits proliferation and results in increased neurogenesis. The identification of ephrin-A2 and EphA7 as negative regulators of progenitor cell proliferation reveals a novel mechanism to control cell numbers in the brain.
Ephrin signalling controls brain size by regulating apoptosis ... - Nature
2005年5月15日 · Here we show that ephrin-A/EphA receptor signalling plays a key role in controlling the size of the mouse cerebral cortex by regulating cortical progenitor cell apoptosis. In vivogain of EphA ...
The role of ephrin-A2 and ephrin-A5 in sensorimotor control
2014年12月15日 · Here we probe the function of ephrin-A2 and ephrin-A5 in the development of the dopaminergic and neuromotor pathways using counts of tyrosine hydroxylase (TH) positive cells in the substantia nigra pars compacta (SNpc) and the ventral tegmental area (VTA), the acoustic startle reflex (ASR), and a measure of sensorimotor gating, prepulse ...
Ephrin-A2 reverse signaling negatively regulates neural progenitor ...
2005年2月15日 · Disrupting the interaction between ephrin-A2 and EphA7 in the adult brain of wild-type mice disinhibits proliferation and results in increased neurogenesis. The identification of ephrin-A2 and EphA7 as negative regulators of progenitor cell proliferation reveals a novel mechanism to control cell numbers in the brain.
Ephrin A2 - an overview | ScienceDirect Topics
In subject area: Neuroscience. Ephrin-A2 is a growth cone repellent and interstitial branching inhibitor located in the caudal tectum/colliculus, which prevents temporal axons from invading this region by activating their EphA receptors. AI generated definition based on: Brain Research Bulletin, 2009. About this page.
Ephrin-A2 regulates excitatory neuron differentiation and interneuron ...
2017年9月18日 · Loss of ephrin-A2 in the pre-optic area of the diencephalon reduced the migration of neocortex-bound interneurons from this region. Furthermore, ephrin-A2 participates in the creation of excitatory neurons by inhibiting apical progenitor proliferation in the ventricular zone, with the disruption of ephrin-A2 signaling in these cells ...
Ephrin-A2 regulates excitatory neuron differentiation and …
2017年9月18日 · Specifically, ephrin-A2 promotes the migration of interneurons emerging from the POA and modulates the proliferation of apical progenitors in the neocortex. We propose that ephrin-A2 acts as a proneural cell fate determinant, with the loss of ephrin-A2 resulting in abnormal neocortical lamination akin to ASD-associated deficits.