Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
Ephrin-B ligands are transmembrane and are linked to an intracellular PDZ-binding motif via a linker containing five tyrosine resides for autophosphorylation. (B) Dimerization of Eph receptors is regulated by various processes including SAM domain interactions, ligand clustering, and interactions between cysteine-rich regions and ephrin binding ...
Ephrin 家族 Ephrin/Eph Family - 知乎 - 知乎专栏
Ephrins 可分为两大类，一种是通过糖基磷脂酰肌醇 (GPI) 部分连接到细胞膜上的ephrinAs (A1-A6)，另一种是跨越细胞膜并拥有细胞质信号域的ephrinBs (B1-B3)。. 在人类基因组中，共有9个EphA 受体和5个EphB受体。. EphA 受体混杂地结合5个Ephrin-A配体，EphB 受体混杂地结合3个 ...
Mechanisms of ephrin–Eph signalling in development ... - Nature
2016年1月21日 · Ephrin–Eph signalling regulates cell migration in neurons, allowing the cells to reach their final destination, guides axons along intermediate choice points to reach their final...
Ephs and ephrins: Current Biology - Cell Press
2017年2月6日 · In the brain, Ephs and ephrins are expressed in complementary patterns, with signalling leading to cell repulsion and, as a result, prevents cell intermingling. Correct expression of Ephs and ephrins is critical in brain development; indeed, loss of EphB2 or EphB3 causes aberrant formation of the cerebral hemispheres.
EphBs and ephrin-Bs: Trans-synaptic organizers of ... - ScienceDirect
2018年9月1日 · Trans-synaptic organizing molecules are important mediators of such signaling. Here we discuss how the EphB and ephrin-B families of trans-synaptic organizing proteins direct synapse formation during early development and regulate synaptic function and plasticity at mature synapses.
Eph Receptors and Ephrins: Therapeutic Opportunities - PMC
The Eph/ephrin system is critical for cardiovascular development, as shown by the heart and blood vessel defects resulting from knockout of Eph receptors or ephrins (63 – 66). Some family members, such as EphA2/ephrin-A1 and EphB4/ephrin-B2, also play key roles in the adult cardiovascular system.
Eph-Ephrin Bidirectional Signaling in Physiology and Disease - Cell …
2008年4月4日 · Ephrin-B2 reverse signaling can be stimulated by interaction with EphB4 expressed in the tumor vasculature and in tumor cells. Indeed, increased levels of the EphB4 extracellular portion on the surface of a cancer cell line have been shown to increase tumor growth through effects on the vasculature.
The Eph/ephrin system symphony of gut inflammation
2023年11月1日 · Eph/ephrin signaling is critical for inflammatory response, neuronal activation, and synaptic plasticity in the brain, but its presence and function in the ENS have been largely unknown to date. This review discusses the critical role of Eph/ephrin in regulating gut homeostasis, inflammation, neuroimmune interactions, and pain pathways.
Eph receptors and ephrins in cancer: bidirectional signalling and ...
This article demonstrates that ephrin-B phosphorylation, owing to reverse signalling or interplay with growth factor receptors, regulates the integrity of epithelial cell–cell junctions.
Ephs, Ephrins, Bidirectional Signaling | Learn Science at Scitable
Like the Eph receptor, Eph-ephrin interaction quickly converts the cytoplasmic presence of ephrin-B from a dormant state to a focal point of active signal transduction, even though the small...