Ephrin 家族 Ephrin/Eph Family - 知乎 - 知乎专栏
Eph/Ephrin信号转导是双向的，在 Eph 受体表达细胞中称为正向信号转导，在 Ephrin 配体表达细胞中称为反向信号转导。 Eph/Ephrin信号通路在发育过程、成体组织稳态和各种疾病中发挥重要作用，它的异常功能与包括癌症在内的各种疾病有关。
Eph Receptors and Ephrins: Therapeutic Opportunities - PMC
A soluble form of the ephrin-A1 ligand (ephrin-A1 Fc) promoted regeneration of the brain dopaminergic neurons that are lost in a rat Parkinson’s model and SNPs in several Eph receptors, including EphB1, have been associated with the disease .
重组人Ephrin A1蛋白(Fc Chimera) (ab181919) - Abcam中文官网
购买Abcam重组人Ephrin A1蛋白(Fc Chimera) (ab181919)，全长蛋白。 1篇文献引用，提供28,000多种信号蛋白、细胞因子、趋化因子、生长因子等产品。 重组人Ephrin A1蛋白(Fc Chimera)| Abcam中文官网
Eph-ephrin signaling couples endothelial cell sorting and arterial ...
2024年4月3日 · Stimulation with recombinant EphB4/Fc fusion protein is known to activate ephrin-B2 reverse signaling, while stimulation with ephrin-B2/Fc leads to activation of the EphB4 kinase and...
Recombinant Human Ephrin-B2 Fc Chimera Protein, CF - R&D …
Ephrin-B2, also known as Htk-L, ELF-2, LERK-5, and NLERK-1, is a 40 kDa member of the Ephrin-B family of transmembrane ligands that bind and induce the tyrosine autophosphorylation of Eph receptors. The extracellular domains of Ephrin-B ligands are structurally related to GPI-anchored Ephrin-A ligands.
Recent advances of the Ephrin and Eph family in cardiovascular ...
2024年8月16日 · By modulating the interaction between Stat3 and transforming growth factor β (TGF-β)/Smad3 signaling pathways, the profibrotic EphrinB2 regulates myofibroblast activation and modulates cardiac fibrosis after MI. 80 Intramyocardial injection of EphrinA1-Fc decreased cardiac fibrosis in wild-type (WT) mice and EphA2 receptor-null mice four ...
Recent advances of the Ephrin and Eph family in cardiovascular ...
The administration of EphrinA1-Fc significantly exacerbated cardiac dysfunction and remodeling after MI in EphA2 receptor-null mice. 81 Conversely, EphrinA1-Fc injection exerted cardioprotection in WT mouse hearts after MI and ischemic/reperfusion (I/R) injury. 81, 84, 122 These findings strongly demonstrated the pivotal role of EphrinA1-EphA2 ...
EphB4 and ephrinB2 act in opposition in the head and neck tumor ...
2022年6月20日 · EphrinB2-Fc (R&D Systems, Minneapolis, MN, USA) is a recombinant protein comprising of an extracellular domain of ephrinB2 dimerized by tagging with the Fc protein of IgG 1.
The EphA2 receptor is activated through induction of distinct, …
2018年2月22日 · The ligand and kinase activity-dependent form of EphA2 signaling involves receptor tyrosine phosphorylation and is potently induced by cell surface-anchored ephrinA ligands, such as ephrinA1, as...
Ephrin-B2/Fc promotes proliferation and migration, and suppresses ...
2017年6月20日 · Cytological experiments further confirm that ephrin-B2/Fc stimulates endothelial cell proliferation, triggers dose-dependent migration, and suppresses cell apoptosis. Results demonstrate that soluble dose-dependent ephrinB2 can promote proliferation and migration and inhibit apoptosis of human umbilical vein endothelial cells.
- 某些结果已被删除