Ephrin receptor - Wikipedia
Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs).
Eph家族受体在机体生理和病理过程中作用机制的研究进展
摘要: 促红细胞生成素肝细胞激酶 (Erythropoietin-producing hepatocellular, Eph)受体家族作为目前已知最大的酪氨酸激酶受体家族，通过受体–配体结合，介导人类从胚胎发育到成人组织稳态诸多生物学功能的调节，参与机体各种免疫反应。. 研究发现，Eph受体在包括神经 ...
Eph Receptor Signaling and Ephrins - PMC - National Center for ...
Eph receptor–ephrin complexes emanate bidirectional signals that affect both receptor- and ephrin-expressing cells. Intriguingly, ephrins can also attenuate signaling by Eph receptors coexpressed in the same cell. Additionally, Eph receptors can modulate cell behavior independently of ephrin binding and kinase activity.
Mechanisms of ephrin–Eph signalling in development ... - Nature
2016年1月21日 · Key Points. Eph Tyr kinases and ephrins can simultaneously act as receptors and ligands, allowing unidirectional or bidirectional signalling, which in turn can lead to parallel and antiparallel...
Eph Receptors and Ephrins: Therapeutic Opportunities
Eph receptors bind ephrins on neighboring cells, generating cell contact-dependent bidirectional signals that regulate cell shape, movement, survival and proliferation (1; 3; 4). Eph “forward” signaling depends on ephrin binding, which induces Eph receptor clustering, autophosphorylation and kinase activity (Figure 1A).
Eph receptor signalling: from catalytic to non-catalytic functions
2019年8月12日 · The erythropoietin-producing hepatoma (Eph) receptor subfamily is the largest amongst the RTKs with 14 members classified into type A and type B. Compared with other RTKs,...
Ephrin Receptor - an overview | ScienceDirect Topics
Ephrin Receptor refers to the largest family of tyrosine kinase receptors, known as Eph receptors, which play a crucial role in various cellular processes such as cell positioning, tissue and organ patterning, control of cell survival, vascular …
Eph receptors and ephrins in cancer progression - Nature
2023年11月23日 · This Review by Elena B. Pasquale outlines the current understanding of Eph receptor–ephrin signalling mechanisms in cancer progression and therapy resistance, and also details therapeutic ...
Ephs and ephrins: Current Biology - Cell Press
2017年2月6日 · Eph receptors are divided into two subfamilies, the type A Eph receptors (EphA1–EphA8 and EphA10), which bind to and activate type A ephrins (ephrin-A1–ephrin-A5), and the type B Eph receptors (EphB1–EphB4 and EphB6), which bind to and activate the type B ephrins (ephrin-B1–ephrin-B3).
Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
2019年7月4日 · Eph receptors are the largest family of receptor tyrosine kinases and mediate a myriad of essential processes in humans from embryonic development to adult tissue homeostasis through interactions with membrane-bound ephrin ligands.