Ephrin A5 - Wikipedia
Ephrin A5 is a glycosylphosphatidylinositol (GPI)-anchored protein of the ephrin-A subclass of ephrin ligands that binds to the EphA subclass of Eph receptors. Ephrin A5 has also been shown to bind to the EphB2 receptor.
Ephrin receptor - Wikipedia
Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs).
Eph家族受体在机体生理和病理过程中作用机制的研究进展
摘要: 促红细胞生成素肝细胞激酶 (Erythropoietin-producing hepatocellular, Eph)受体家族作为目前已知最大的酪氨酸激酶受体家族，通过受体–配体结合，介导人类从胚胎发育到成人组织稳态诸多生物学功能的调节，参与机体各种免疫反应。 研究发现，Eph受体在包括神经系统发育、细胞迁移、血管形成等许多生理发育过程中起重要作用，在调节免疫反应、肿瘤、炎症、损伤修复等病理过程中也发挥着重要功能。 进一步深入的研究Eph家族受体的生物学功能能够更好的对临床疾病 …
Ephrin Receptor A5 - an overview | ScienceDirect Topics
Ephrin Receptor A5 is a receptor expressed in neurons that can cause axon repulsion in the presence of Ephrin-A5, actively excluding certain types of afferents from specific regions of the brain. AI generated definition based on: Developmental Biology , 2003
Eph receptor signalling: from catalytic to non-catalytic functions
2019年8月12日 · Human EphA receptors (EphA1–A8 and EphA10) preferentially bind to the ephrin A ligands, whereas human EphB receptors (EphB1–B4 and EphB6) bind to the ephrin B ligands. However, promiscuous...
Eph Receptor Signaling and Ephrins - PMC - National Center for ...
Eph receptor–ephrin complexes emanate bidirectional signals that affect both receptor- and ephrin-expressing cells. Intriguingly, ephrins can also attenuate signaling by Eph receptors coexpressed in the same cell. Additionally, Eph receptors can modulate cell behavior independently of ephrin binding and kinase activity.
Eph Receptors and Ephrins: Therapeutic Opportunities
Eph receptors bind ephrins on neighboring cells, generating cell contact-dependent bidirectional signals that regulate cell shape, movement, survival and proliferation (1; 3; 4). Eph “forward” signaling depends on ephrin binding, which induces Eph receptor clustering, autophosphorylation and kinase activity (Figure 1A).
The Ephrin-A5/EphA4 Interaction Modulates Neurogenesis and ... - PubMed
In summary, interaction between ephrin-A5 and EphA4 could mediate the ERK and Akt signaling pathways in pilocarpine-induced epilepsy, and intervention of the ephrin/Eph interaction may play an essential role in the suppression of newborn neuron generation, microvessel remodeling, and SRS in a mouse model of TLE.
Ephs and ephrins: Current Biology - Cell Press
2017年2月6日 · Eph receptors are divided into two subfamilies, the type A Eph receptors (EphA1–EphA8 and EphA10), which bind to and activate type A ephrins (ephrin-A1–ephrin-A5), and the type B Eph receptors (EphB1–EphB4 and EphB6), which bind to and activate the type B ephrins (ephrin-B1–ephrin-B3).
A role for ephrin-A5 in axonal sprouting, recovery, and activity ...
2012年8月8日 · We show that ephrin-A5 is induced in reactive astrocytes in periinfarct cortex and is an inhibitor of axonal sprouting and motor recovery in stroke.