Mechanisms of ephrin–Eph signalling in development ... - Nature
2016年1月21日 · The ventral limb expresses ephrin-A ligands, which repel EphA-expressing motor axons into the dorsal nerve 86,87, whereas the dorsal limb expresses ephrin-Bs, which repel EphB-expressing...
Ephrin - Wikipedia
Ephrins (also known as ephrin ligands or Eph family receptor interacting proteins) are a family of proteins that serve as the ligands of the Eph receptor. Eph receptors in turn compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs).
Ephs and ephrins: Current Biology - Cell Press
2017年2月6日 · Learn about the structure, function and signalling of Eph receptors and ephrin ligands, the largest family of receptor tyrosine kinases. Discover how Ephs and ephrins regulate cell–cell adhesion, guidance, migration and disease.
Ephrins and their Eph receptors: multitalented directors of …
1999年10月1日 · Ephrin‐A2 was also found to repel retinal axons both in vitro and in vivo when ectopically expressed with a retroviral vector (Nakamoto et al., 1996). These initial experiments have been extended and there are now ample examples of axons from different neuronal types that are repelled by ephrins ( Flanagan and Vanderhaegen, 1998 ).
Ephrin receptor - Wikipedia
Eph/ephrin signaling regulates the migration of axons to their target destinations largely by decreasing the survival of axonal growth cones and repelling the migrating axon away from the site of Eph/ephrin activation.
Multiple roles of ephrins in morphogenesis, neuronal networking, …
The ephrin–Eph system is unique among the RTK family mainly for two reasons: First, ephrinB ligands (and perhaps also ephrinAs) not only induce signaling downstream of the Eph receptors (forward signaling), but also signal themselves into the cell that expresses them—referred to as reverse signaling (see below).
Eph receptors and ephrins in cancer progression - Nature
2023年11月23日 · This Review by Elena B. Pasquale outlines the current understanding of Eph receptor–ephrin signalling mechanisms in cancer progression and therapy resistance, and also details therapeutic ...
Mechanisms and functions of eph and ephrin signalling
2002年7月1日 · Expression data supported the conclusions that ephrinB3 functions in the spinal cord as a cell-attached midline repellent for EphA4-expressing neurons.
Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity
2019年7月3日 · Eph receptors are the largest family of receptor tyrosine kinases that regulate cellular processes through interactions with ephrin ligands. This review summarizes the roles of Eph receptors and ephrin ligands in immune cell development, activation, and migration, as well as their implications in disease and immunotherapy.
Ephrin reverse signaling in axon guidance and synaptogenesis
Distinct ephrin-mediated reverse signaling in dendrites. Ephrin-A molecules are able to interact with TrkB receptors in neurons and promote synapse formation. Ephrin-B molecules transduce reverse signals to mediate both dendrite pruning and spinogenesis.