FGF/FGFR signaling in health and disease - Nature
2020年9月2日 · Fibroblast growth factors (FGFs) are broad-spectrum mitogens and regulate a wide range of cellular functions, including migration, proliferation, differentiation,...
The Fibroblast Growth Factor signaling pathway - PMC
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs). Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins.
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency
FGF signaling is mediated by the activation of RAS – mitogen-activated protein kinase (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-AKT, Phospholipase C Gamma (PLCγ), and signal transducers and activators of transcription (STAT), which intersects and synergizes with other signaling pathways such as Wnt, retinoic acid (RA) and ...
FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency
2020年2月18日 · FGF/FGFR signaling governs fundamental cellular processes such as cell survival, proliferation, migration, differentiation, embryonic development, organogenesis, tissue repair/regeneration, and metabolism.
The Fibroblast Growth Factor signaling pathway - PubMed
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs). Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofacto …
Structural basis for FGF hormone signalling | Nature
2023年6月7日 · Our structural and biochemical data overturn the current symmetric FGFR dimerization paradigm and provide blueprints for rational discovery of modulators of FGF signalling 2 as therapeutics for...
Fibroblast growth factor signalling: from development to cancer
2010年2月1日 · Fibroblast growth factors (FGFs) and their receptors (FGFRs) drive crucial developmental signalling pathways, which are responsible for many functions, including cell...
FGF/FGFR signaling in health and disease - PubMed
2020年9月2日 · In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD).
Understanding FGF Signaling: A Key Pathway in Development …
This blog offers an overview of FGF signaling and subsequent downstream signaling pathways, focusing on their roles in homeostasis, cancer progression, and therapeutic implications of targeting FGF signaling.
Fibroblast Growth Factor (FGF) Family Signaling Pathways - R&D …
A graphic showing the signaling pathways activated by FGF family proteins, the receptor binding specificities for each FGF ligand, and their suggested functions.
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