(S)-5- ( (1- (4,4-difluoro-3- (3-fluoro-1H-pyrazol-1-yl)butanoyl)-4 ...
2021年10月14日 · (S)-5-((1-(4,4-difluoro-3-(3-fluoro-1H-pyrazol-1-yl)butanoyl)-4-hydroxypiperidin-4-yl)methyl)-1-(4-fluorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | C24H23F4N7O3 | CID 121457027 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity ...
FT671 | CAS#:1959551-26-8 | Chemsrc - 化源网
2024年1月11日 · FT671 is a potent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM. FT671 binds to the USP7 catalytic domain (USP7CD; residues 208-560) with apparent dissociation constant …
Molecular basis of USP7 inhibition by selective small-molecule
2017年10月18日 · Here we report that two compounds, FT671 and FT827, inhibit USP7 with high affinity and specificity in vitro and within human cells. Co-crystal structures reveal that both compounds target a...
USP7-inhibitor complex structures. a, Overall structure of …
The PyrzPPip scaffold of non-covalent FT671 (Fig. 2d) is extended towards the Fingers subdomain by a para-fluorophenyl group, and towards the catalytic centre by a 3-fluoropyrazole group that...
RCSB PDB - 5NGE: Crystal structure of USP7 in complex with the …
Consistent with USP7 target engagement in cells, FT671 destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes, induction of the tumour suppressor p21, and inhibition of tumour growth in mice.
FT-671 | 1959551-26-8 - ChemicalBook
FT-671 | 1959551-26-8 - chemical and physical properties, structure, melting point, boiling point, density, molecular formula, molecular weight, uses, prices, suppliers, and toxicity/safety/hazards/SDS information.
FT671 | CAS NO.:1959551-26-8 - GlpBio
FT671 is a potent, non-covalent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the USP7 catalytic domain with a Kd of 65 nM.
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FT671_化工百科 - ChemBK
中文名:FT671,英文名:FT671,CAS:1959551-26-8,FT671 is a potent, non-covalent and selective USP7 inhibitor with an IC50 of 52 nM and binds to the .化学式:C24H23F4N7O3,分子量:533.48,密度:1.56±0.1 g/cm3 (Predicted),沸点:719.8±70.0 °C (Predicted),MSDS.
FT-671 | USP7 inhibitor | Probechem Biochemicals
FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain). FT-671 inhibits USP7 with IC50 values of 52 nM (USP7 CD) and 69 nM (USP7C-term), display good USP7 selectivity in a panel of 38 deubiquitinases (DUBs).
Probe FT671 | Chemical Probes Portal
note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars. Probe FT671 is in the process of SERP review.
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