10+纯生信，结合单细胞+bulk数据，基于“gene pair ”建模并进行 …
2023年6月18日 · 本研究旨在通过将单细胞技术与普通转录组测序的预后数据相结合，开发临床有效的基因对特征（GP特征）以评估胶质母细胞瘤GBM患者的预后，并研究肿瘤相关免疫与GP …
Gene-pair expression signatures reveal lineage control
We curated human expression data comprising 166 cell types and 2,602 transcription-regulating genes and developed a data-driven method for identifying putative determinants of cell fate …
利用稀疏矩阵分解对单细胞数据构建基因共表达网络 - 知乎
构建基因共表达网络（gene co-expression networks)是一种常见的RNA-seq数据分析方法，在这个网络中，node代表gene，共表达的gene pair之间用edge相连。 这样一个网络，常用在推 …
Gene-pair expression signatures reveal lineage control
2013年4月21日 · We expected gene pairs that function as lineage determinants to exhibit consistent relative expression across samples from the same cell type (and lineage) and …
基于gene-pair差异评分的机器学习预测AML发病风险 - 搜狐
2019年3月15日 · 选择的最佳的一个或N个可用于预测的gene pair就是Top-scoring pair方法。 CytoPred基于这个TSP的决策树方法从大量的表达矩阵中筛选能对AML（急性髓细胞性白血 …
【PNAS】一种基于单细胞表达数据推断基因间关系的深度学习方 …
CNNC input, output, and architecture. CNNC aims to infer gene– gene relationships using single-cell expression data. For each gene pair, scRNA-seq expression levels are transformed into …
Synthetic lethal gene pairs: Experimental approaches and …
We extensively reviewed experimental technologies, public data sources, and predictive models in the study of synthetic lethal gene pairs and herein detail biological assumptions, experimental …
Gene pair signatures in cell type transcriptomes reveal lineage …
We compiled a resource of curated human expression data comprising 166 cell types and 2,602 transcription regulating genes and developed a data driven method built around the concept of …
Nuclear gene proximity and protein interactions shape transcript ...
2020年10月28日 · Here the authors analyze intrinsically covarying gene pairs by eliminating the confounding effects in single-cell experiments and observe covariation of proximal genes and …
Transcriptome-wide gene-gene interaction associations elucidate …
2023年5月22日 · Here, we introduce a new approach using predicted gene expression to perform exhaustive transcriptome-wide interaction studies (TWISs) for multiple traits across all pairs of …