Direct control of lysosomal catabolic activity by mTORC1 through ...
2022年8月17日 · Here, we show that mTORC1 blocks lysosomal degradation of extracellular proteins by suppressing V-ATPase-mediated acidification of lysosomes. When mTORC1 is active, peripheral V-ATPase V 1...
mTOR and lysosome regulation - PMC - National Center for …
2014年7月8日 · Recent evidence suggests that mTORC1 serves as a negative regulator of lysosomal function. Zhou and colleagues compared lysosomal function between fed and starved cells by measuring lysosomal acidification, cathepsin activity, and rate of proteolysis [30].
mTOR and lysosome regulation - PubMed
2014年7月8日 · Lysosomes are key cellular organelles that play a crucial role in catabolism by degrading extracellular and intracellular material. It is, therefore, very intriguing that mTORC1 (mechanistic target of rapamycin complex 1), a major promoter of anabolic processes, localizes in its active form to the surface of lysosomes.
Amino acid-dependent control of mTORC1 signaling: a variety of ...
2020年8月17日 · mTORC1 regulates cell growth and metabolism by modulating protein, lipid, and purine synthesis, as well as lysosome biogenesis and autophagy (Fig. 1 b). mTORC1 activity is influenced by a variety of signals such as amino acids, glucose, growth factors, energy levels, and stresses [2, 12, 13, 14, 15, 16, 17, 18].
Rap1-GTPases control mTORC1 activity by coordinating lysosome ... - Nature
2020年3月17日 · The kinase mTOR complex 1 (mTORC1) promotes cellular growth and is frequently dysregulated in cancers. In response to nutrients, mTORC1 is activated on lysosomes by Rag and Rheb guanosine...
Targeting lysosomes in human disease: from basic research to …
2021年11月8日 · Target mTOR signaling. Lysosomes serve as platforms for the proper recruitment, assembly, and activation of mTOR signaling elements, and mTOR acts as a nutrient sensor that regulates the ...
The lysosome: a crucial hub for AMPK and mTORC1 signalling
2017年4月13日 · Much is now understood about how the lysosome contributes to amino acid sensing by mTORC1, the involvement of the energy-sensing kinase, AMP-activated protein kinase (AMPK), at the lysosome and how both AMPK and mTORC1 signalling pathways feedback to lysosomal biogenesis and regeneration following autophagy.
Non-canonical mTORC1 signaling at the lysosome - Cell Press
2022年5月30日 · Non-canonical mTORC1 signaling responds to stimuli that converge on the lysosomal surface. Rag GTPases mediate a novel mTORC1 substrate-recruitment mechanism. Deregulation of non-canonical mTORC1 signaling underlies the pathogenesis of different types of inherited diseases and cancer.
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out ... - Science
2011年11月4日 · The mTOR complex 1 (mTORC1) protein kinase is a master growth regulator that is stimulated by amino acids. Amino acids activate the Rag guanosine triphosphatases (GTPases), which promote the translocation of mTORC1 to the lysosomal surface, the site of mTORC1 activation.
Nutrient-regulated control of lysosome function by signaling lipid ...
2023年10月25日 · We show here that lysosome morphology and function are reversibly controlled by a nutrient-regulated signaling lipid switch that triggers the conversion between peripheral motile mTOR complex 1 (mTORC1) signaling-active and static mTORC1-inactive degradative lysosomes clustered at the cell center.