The Primary Motor Cortex: The Hub of Motor Learning in Rodents
2022年3月1日 · Mice are expected to show an increased success rate in grasping the food pellet and decreased variance in forelimb movement trajectory with motor learning (Li et al., 2017). Moreover, the forelimb reaching task is popularly modified by replacing the food pellet with a joystick, lever, and manipulandum ( Slutzky et al., 2010 , Kimura et al ...
Impact of enriched environment on motor performance and learning in mice
2024年3月12日 · Our results indicate that environmental enrichment, including the use of the running wheel, indeed affected motor learning and improved motor performance on the accelerating rotarod and...
Motor learning selectively strengthens cortical and striatal …
2022年9月7日 · To study how motor learning modulates corticostriatal connectivity, we selectively expressed channelrhodopsin 2 (ChR2) in M1 TRAP neurons by injecting AAV5-DIO-ChR2-mCherry into the motor cortex of c-Fos-CreER mice (Figure 3 A) and administering 4-OHT at early or late stages of training or in control mice (Figure 1 A). Since engram neuron ...
Locomotor activity modulates associative learning in mouse
2018年4月16日 · Increased locomotor speed in head-fixed mice drove earlier onset of learning and trial-by-trial enhancement of learned responses that were dissociable from changes in arousal and independent of...
Exercise training improves motor skill learning via selective
Physical exercise improves learning and memory, but little in vivo evidence has been provided to illustrate the molecular mechanisms. Here, we show that chronic treadmill exercise activates the mechanistic target of rapamycin (mTOR) pathway in mouse motor cortex.
Mice, motor learning, and making decisions - Research Blog
2018年2月28日 · Komiyama and his lab have designed experiments to watch how the brain changes as mice learn. Specifically, they train mice to complete a lever-pushing task in response to an auditory stimulus and then use an advanced imaging technique to watch the activity of specific populations of neurons.
Developmental changes in mouse motor skill learning and …
2024年7月19日 · This study assesses the normal developmental trajectory of motor learning and then addresses inhibitory connectivity changes after motor learning. We trained mice of both sexes to run on a custom accelerating rotarod at ages from postnatal day (P) 20 to P120, tracking paw position and quantifying time to fall and changes in gait pattern.
mTOR signaling contributes to motor skill learning in mice
2014年4月3日 · The present study establishes, by using two different pharmacological and one genetic approaches, that mTOR activity of the dorsal striatum is one important molecular step involved in learning consolidation, but not motor abilities, during the acquisition of a complex motor skill in mice.
mTOR signaling contributes to motor skill learning in mice
2014年4月3日 · The mammalian target of rapamycin (mTOR) kinase is a critical regulator of mRNA translation and is suspected to be involved in various long-lasting forms of synaptic and behavioral plasticity. However, its role in motor learning and control has never been examined. This study investigated, in mice, …
Motor skill learning requires active central myelination | Science
2014年10月17日 · Learning a new motor skill (such as juggling) alters the structure of the brain’s white matter, which contains many OLs, suggesting that late-born OLs might contribute to motor learning. Consistent with this idea, we show that production of newly formed OLs is briefly accelerated in mice that learn a new skill (running on a “complex wheel ...