Landscape of disturbed pathways in AOM/DSS mouse model …
Comparisons of five key pathways in human CRC and two most enriched pathways in AOM/DSS mouse model among three groups of human CRC and AOM/DSS mice in their frequencies (B) and patterns of...
Mouse DSS model data a, ML349 toxicity study. C57BL/6J mice …
This study investigated the direct targets and mechanism through which 1,8-cineole exerts its anti-inflammatory effects using a dextran sulfate sodium salt (DSS)-induced colitis mouse model.
AOM/DSS Model of Colitis-Associated Cancer - PubMed
Chemical models, in particular, have enabled fast and efficient analysis of genetic and environmental modulators of CAC without the added requirement of time-intensive genetic crossings. Here we describe the Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS) mouse model of inflammatory colorectal cancer.
Conserved transcriptomic profile between mouse and human ... - Nature
2019年6月28日 · Here, using transcriptomic data from a well-characterized experimental model of colitis, we identify conserved genes between mouse and UC patients. As a result, we offer insights into IBD-risk...
Dextran sodium sulfate colitis murine model: An indispensable …
The most widely used mouse model of colitis employs dextran sodium sulfate (DSS), a chemical colitogen with anticoagulant properties, to induce epithelial damage. The DSS colitis model lends itself to IBD research due to its rapidity, simplicity, reproducibility and controllability.
Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks
A quantitative histological analysis of DSS-induced colitis in nine mouse strains using a standardized protocol (3.5% DSS of 36–45 kDa molecular weight for 5 days) demonstrated major differences in DSS responsiveness among strains .
Landscape of somatic mutant genes in AOM/DSS mouse model …
Mouse model induced by azoxymethane (AOM) and dextran sodium sulfate (DSS) is generally accepted as an ideal object to study on the carcinogenesis mechanisms of human colorectal cancer (CRC)....
Chemically induced mouse models of intestinal inflammation
2007年3月15日 · Here, we provide protocols for establishing murine 2,4,6-trinitro benzene sulfonic acid (TNBS)-, oxazolone- and both acute and chronic dextran sodium sulfate (DSS) colitis, the most widely used...
Establishment and histopathological evaluation of AOM/DSS mouse model ...
Mouse model induced by azoxymethane (AOM) and dextran sodium sulfate (DSS) is generally accepted as an ideal object to study on the carcinogenesis mechanisms of human colorectal cancer (CRC)....
Expanding the utility of the dextran sulfate sodium (DSS) mouse model ...
2020年3月10日 · Many animal studies of IBD use a dextran sulfate sodium (DSS) mouse model of colitis that induces rapid and severe colitis symptoms. Although the typical seven-day DSS model is appropriate for many studies, it destroys intestinal barrier function and results in intestinal permeability that is substantially higher than what is typically observed ...