Phosphoinositide-dependent kinase-1 - Wikipedia
PDPK1 is a master kinase, which is crucial for the activation of AKT /PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signaling pathways activated by several growth factors and hormones including insulin signaling.
PDK1 Gene - GeneCards | PDK1 Protein | PDK1 Antibody
5 天之前 · Complete information for PDK1 gene (Protein Coding), Pyruvate Dehydrogenase Kinase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Activation of the essential kinase PDK1 by phosphoinositide …
2022年4月6日 · PDK1 (3-phosphoinositide-dependent kinase 1) is a serine/threonine-protein kinase that plays a central role in regulating cell growth, survival, and proliferation. Knocking out PDK1 in mice...
丙酮酸脱氢酶激酶 1（PDK1）基因 | MCE - MCE-生物活性 ...
丙酮酸脱氢酶 (PDH) 是一种线粒体多酶复合物，可催化丙酮酸的氧化脱羧作用，是负责调节哺乳动物碳水化合物燃料稳态的主要酶之一。 酶活性受磷酸化/去磷酸化循环的调节。 特定丙酮酸脱氢酶激酶 (PDK) 对 PDH 的磷酸化导致失活。 已发现该基因的多个选择性剪接转录物变体。 [RefSeq 提供，2013 年 6 月]
PDK1 pyruvate dehydrogenase kinase 1 [ (human)] - National …
PDK1 is frequently upregulated in primary nasopharyngeal carcinoma and may serve as a prognostic marker. A new function for PDK1 in metabolic reprogramming, which could be used to indicate the prognosis of Non small cell lung cancer and provide targeted therapeutic strategy for clinical treatment.
The Glycolytic Gatekeeper PDK1 defines different metabolic states ...
2022年3月1日 · Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a...
PDK1: At the crossroad of cancer signaling pathways - PubMed
An increasing amount of evidence hints at 3-phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) as an intriguing and underexplored target for cancer therapy. Several reports show that PDK1 expression is dysregulated in multiple cancer types.
PDK1 pyruvate dehydrogenase kinase 1 [ Homo sapiens (human) ]
2024年11月27日 · Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle.
Pyruvate dehydrogenase lipoamide kinase isozyme 1 - Wikipedia
PDK1 is relevant in a variety of clinical conditions throughout the body. As PDK1 regulates the PDH complex, it has been proven to be an important regulator in certain cells, including the beta cells within the islets of the pancreas.
PDK1结构与功能研究进展 - 百度学术
pdk1是agc蛋白激酶家族里面的一个丝氨酸/苏氨酸激酶。pdk1与pip3的结合对于有效激活akt等激酶,从而控制细胞生长、分化、生存、蛋白质翻译和葡萄糖代谢具有重要意义。本综述对pdk1的结构和功能进行了介绍,对于了解pdk1以及其调控的相关信号通路分子具有重要意义。